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<p>Cerebral hypoxia and <!--Query ID="Q1" Text="Please check if the author name and affiliation are captured and presented correctly." Resolved="yes"-->ischemia are critical pathological factors in the etiology of Alzheimer disease. Common types of dysfunctional respiration, such as hyperventilation, oral breathing, thoracic breathing and hypoventilation have been shown to induce cerebral hypoxia and ischemia. Therefore, it is proposed that these respiratory abnormalities are risk factors in the pathogenesis of Alzheimer disease. Consequently, correcting these respiratory abnormalities could counteract the pathogenesis of Alzheimer disease in vulnerable populations. These therapeutic strategies might also be applicable to other types of degenerative dementia that share pathomechanisms with Alzheimer disease, e.g., dementia with Lewy bodies, frontotemporal dementia and vascular dementia.</p>

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Dysfunctional respiration as a risk factor for Alzheimer disease: a hypothesis

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Gregory W. Konat

摘要

Cerebral hypoxia and ischemia are critical pathological factors in the etiology of Alzheimer disease. Common types of dysfunctional respiration, such as hyperventilation, oral breathing, thoracic breathing and hypoventilation have been shown to induce cerebral hypoxia and ischemia. Therefore, it is proposed that these respiratory abnormalities are risk factors in the pathogenesis of Alzheimer disease. Consequently, correcting these respiratory abnormalities could counteract the pathogenesis of Alzheimer disease in vulnerable populations. These therapeutic strategies might also be applicable to other types of degenerative dementia that share pathomechanisms with Alzheimer disease, e.g., dementia with Lewy bodies, frontotemporal dementia and vascular dementia.