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<p>Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a complex immune-mediated inflammatory disorder characterized by chronic inflammatory infiltration, oxidative stress, and neuropathic pain in prostate tissue. Elucidating novel pathological mechanisms to develop effective therapeutic strategies remains an urgent research priority. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has recently been implicated in the pathogenesis of various chronic inflammatory conditions. Emerging evidence indicates that ferroptosis activation contributes significantly to CP/CPPS progression, suggesting its targeted regulation as a promising therapeutic approach. However, the precise mechanisms through which ferroptosis regulates chronicity and tissue damage in CP/CPPS require systematic elucidation. This review therefore focuses on elucidating the potential role of ferroptosis in CP/CPPS pathogenesis. We further examine specific pathological evidence linking ferroptosis to prostatitis. Finally, promising compounds that may act as ferroptosis inhibitors in CP/CPPS are summarized.</p>

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Ferroptosis in prostatitis: pathogenic mechanisms and therapeutic advances

  • 期刊论文

  • 发表日期：

    2026年3月21日

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  • Jintao Shi,
  • Qinyu Zhang,
  • Yang Xuan,
  • Hao Zhang,
  • Yue Duan

摘要

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a complex immune-mediated inflammatory disorder characterized by chronic inflammatory infiltration, oxidative stress, and neuropathic pain in prostate tissue. Elucidating novel pathological mechanisms to develop effective therapeutic strategies remains an urgent research priority. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has recently been implicated in the pathogenesis of various chronic inflammatory conditions. Emerging evidence indicates that ferroptosis activation contributes significantly to CP/CPPS progression, suggesting its targeted regulation as a promising therapeutic approach. However, the precise mechanisms through which ferroptosis regulates chronicity and tissue damage in CP/CPPS require systematic elucidation. This review therefore focuses on elucidating the potential role of ferroptosis in CP/CPPS pathogenesis. We further examine specific pathological evidence linking ferroptosis to prostatitis. Finally, promising compounds that may act as ferroptosis inhibitors in CP/CPPS are summarized.