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<p>SUMOylation (SUMO), a crucial post-translational modification, is implicated in the regulation of diverse biological processes and plays a pivotal role in both the maintenance of cardiac function and progression and treatment of heart disease. Here, we reviewed the mechanisms by which SUMO-related various aspects of cardiac function and disease, including cardiac hypertrophy, heart failure, ischemia–reperfusion injury, and myocardial infarction. Furthermore, we highlight its potential as a therapeutic target.</p> Graphical Abstract <p></p>

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The multifaceted nature of SUMOylation in heart disease and its therapeutic potential

  • 期刊论文

  • 发表日期：

    2025年4月27日

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  • Ying He,
  • Zhijie Yang,
  • Dan Guo,
  • Cheng Luo,
  • Qiaoqiao Liu,
  • Lei Xian,
  • Fan Yang,
  • Chusheng Huang,
  • Qingjun Wei

摘要

SUMOylation (SUMO), a crucial post-translational modification, is implicated in the regulation of diverse biological processes and plays a pivotal role in both the maintenance of cardiac function and progression and treatment of heart disease. Here, we reviewed the mechanisms by which SUMO-related various aspects of cardiac function and disease, including cardiac hypertrophy, heart failure, ischemia–reperfusion injury, and myocardial infarction. Furthermore, we highlight its potential as a therapeutic target.

Graphical Abstract