<p>A tube reinforced hyperelastic gradient porous sandwich structure (TRHGP) for shock isolation of gearbox is proposed based on the principles of bionics. The perfusion–moulding press integrated molding process is developed to prepare the specimens. This process is simple and conducive to industrialization. Moreover, the dynamic responses and shock isolation efficiencies of TRHGPs connected to a gearbox under different shock acceleration amplitudes are investigated experimentally and numerically. The effects of topological configuration, porosity, and impact load on the shock resistance performance of TRHGPs are also explored. The results indicate that, compared with the response under rigid impact condition, the shock isolation efficiency of TRHGPs is more than 40%. Furthermore, it is demonstrated that the TRHGP with triangular tubes exhibits better shock isolation efficiency than those with rectangular or circular tubes. The findings provide a valuable reference for the design of shock isolation structures.</p>