Objective <p>Unintentional injury poses a health threat to children, and toddlerhood (2 to 4 years) is a particularly vulnerable period. At this stage, parental intervention and monitoring are essential for mitigating injury risk. Maternal depressive symptoms are associated with greater frequency of injuries to young children in the home, however, our understanding of why remains limited. This study examined associations between maternal depressive symptoms and reactions to children’s injury-risk behaviors, as well as children’s injury rates.</p> Method <p>The sample comprised 84 mothers of children (24–47 months) and included a broad range of scores for symptoms of depression. Participants provided questionnaire and observational data.</p> Results <p>Mothers with more elevated depressive symptoms had children who experienced higher injury rates. These mothers showed frequent reactions to intervene when children were engaging in risk behaviors, however, they responded with ineffective strategies (i.e., increased prohibitions, reduced teaching).</p> Conclusion <p>Mothers having greater depressive symptoms focused more on stopping children’s risk behaviors than teaching about safety, and children had higher injury rates.</p>