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Introduction <p>Social factors impact survival for infants with birth defects. This analysis describes the impact of social factors on one-year survival for infants with congenital diaphragmatic hernia (CDH), transposition of the great arteries (TGA), and tetralogy of Fallot (TOF).</p> Methods <p>Survival estimates were generated using the Kaplan-Meier method and the log-rank test with 0.05 significance stratified by social factors for infants born 2011–2019 with CDH (<i>N</i> = 942), TGA (<i>N</i> = 1,102), or TOF (<i>N</i> = 1,545). Crude hazard ratios (HR) and adjusted hazard ratios (AHR) with 95% confidence intervals (CI) were calculated for infant death using the Cox proportional hazards models.</p> Results <p>One-year survival was 88.7% for TOF, 88.0% for TGA, and 72.7% for CDH. Infants with CDH whose mother resided along the Texas-Mexico border had an increased risk of death compared to non-border residents (HR = 1.68, <i>p</i> =.003). Lower maternal education attainment was associated with increased risk of death for infants with TGA (HR = 1.75, <i>p</i> =.002) or TOF (HR = 1.54, <i>p</i> =.005) compared to infants whose mother had more than a high school education. Maternal Hispanic ethnicity increased the risk of death for infants with TGA (HR = 1.75, <i>p</i> =.005) or TOF (HR = 1.74, <i>p</i> =.002) compared to NH White infants.</p> Discussion <p>Hispanic maternal ethnicity, lower maternal educational attainment, and residence along the Texas-Mexico border negatively impact infant one-year survival.</p>

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Assessing the Impact of Social Factors on Survival Among Infants Born with Transposition of the Great Arteries, Tetralogy of Fallot, and Diaphragmatic Hernia in Texas, 2011–2019

  • 期刊论文

  • 发表日期：

    2025年7月9日

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  • Dayana Betancourt,
  • Charles Shumate,
  • Mark A. Canfield,
  • Alva Ferdinand,
  • Robin Page,
  • Theresa Morris,
  • Susan Ayres,
  • Samiran Sinha

摘要

Introduction

Social factors impact survival for infants with birth defects. This analysis describes the impact of social factors on one-year survival for infants with congenital diaphragmatic hernia (CDH), transposition of the great arteries (TGA), and tetralogy of Fallot (TOF).

Methods

Survival estimates were generated using the Kaplan-Meier method and the log-rank test with 0.05 significance stratified by social factors for infants born 2011–2019 with CDH (N = 942), TGA (N = 1,102), or TOF (N = 1,545). Crude hazard ratios (HR) and adjusted hazard ratios (AHR) with 95% confidence intervals (CI) were calculated for infant death using the Cox proportional hazards models.

Results

One-year survival was 88.7% for TOF, 88.0% for TGA, and 72.7% for CDH. Infants with CDH whose mother resided along the Texas-Mexico border had an increased risk of death compared to non-border residents (HR = 1.68, p =.003). Lower maternal education attainment was associated with increased risk of death for infants with TGA (HR = 1.75, p =.002) or TOF (HR = 1.54, p =.005) compared to infants whose mother had more than a high school education. Maternal Hispanic ethnicity increased the risk of death for infants with TGA (HR = 1.75, p =.005) or TOF (HR = 1.74, p =.002) compared to NH White infants.

Discussion

Hispanic maternal ethnicity, lower maternal educational attainment, and residence along the Texas-Mexico border negatively impact infant one-year survival.