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Background <p>The increasing global threat of multidrug-resistant (MDR) infections, diseases caused by oxidative stress, and cancer highlights the urgent need to create novel, efficacious, and safe treatment agents.</p> Aim of study <p>In the present study, we describe the broad range of bioactivity (antimicrobial, antioxidant, and anticancer) of a purified bacteriocin from <i>Lactiplantibacillus plantarum</i>.</p> Method <p>Purification of bacteriocin using Ion exchange chromatography and demonstrated its activities against MDR <i>Staphylococcus epidermidis</i> and <i>Candida albicans</i> by agar well diffusion assay. Antioxidant using DPPH and anticancer assay against A549 lung cancer cells were performed. Human red blood cells were used to evaluate the cytotoxicity of the bacteriocin in vitro.</p> Results <p>The purified bacteriocin (~40 kDa) exhibited strong antibacterial activity against clinical MDR <i>Staphylococcus epidermidis</i>, with a 22 mm ±SD growth inhibitory zone and low inhibitory (31.25 μg/ml) and 62.5 μg/ml bactericidal concentrations. The antifungal effects against <i>Candida albicans</i> displayed an inhibition zone of15 mm ±SD. In addition to its antimicrobial effects, the bacteriocin possessed high antioxidant potential, with over 78% scavenging of DPPH radicals. The bacteriocin demonstrated promising anticancer effects on A549 lung cancer cells via the MTT assay. Importantly, hemocompatibility tests demonstrated its nonhemolytic nature, indicating a good safety profile.</p> Conclusion <p>These findings demonstrated that this bacteriocin, which is isolated from <i>Lactiplantibacillus plantarum</i>, has potential as a natural biotherapeutic agent and possesses biomedical activities, such as antibacterial, antifungal, antioxidant, and anticancer properties, which may have translational significance in conventional medicine.</p>

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A Multifunctional Natural Bioactive Peptide with Antimicrobial, Antioxidant, and Anticancer Activities and Favorable Hemocompatibility

  • 期刊论文

  • 发表日期：

    2026年2月4日

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  • Mohammed Ameer Abdullah,
  • Maisam B. Al-Khamesi,
  • Ghufran Mudher Khalaf,
  • Sana M. H. Al-Shimmary

摘要

Background

The increasing global threat of multidrug-resistant (MDR) infections, diseases caused by oxidative stress, and cancer highlights the urgent need to create novel, efficacious, and safe treatment agents.

Aim of study

In the present study, we describe the broad range of bioactivity (antimicrobial, antioxidant, and anticancer) of a purified bacteriocin from Lactiplantibacillus plantarum.

Method

Purification of bacteriocin using Ion exchange chromatography and demonstrated its activities against MDR Staphylococcus epidermidis and Candida albicans by agar well diffusion assay. Antioxidant using DPPH and anticancer assay against A549 lung cancer cells were performed. Human red blood cells were used to evaluate the cytotoxicity of the bacteriocin in vitro.

Results

The purified bacteriocin (~40 kDa) exhibited strong antibacterial activity against clinical MDR Staphylococcus epidermidis, with a 22 mm ±SD growth inhibitory zone and low inhibitory (31.25 μg/ml) and 62.5 μg/ml bactericidal concentrations. The antifungal effects against Candida albicans displayed an inhibition zone of15 mm ±SD. In addition to its antimicrobial effects, the bacteriocin possessed high antioxidant potential, with over 78% scavenging of DPPH radicals. The bacteriocin demonstrated promising anticancer effects on A549 lung cancer cells via the MTT assay. Importantly, hemocompatibility tests demonstrated its nonhemolytic nature, indicating a good safety profile.

Conclusion

These findings demonstrated that this bacteriocin, which is isolated from Lactiplantibacillus plantarum, has potential as a natural biotherapeutic agent and possesses biomedical activities, such as antibacterial, antifungal, antioxidant, and anticancer properties, which may have translational significance in conventional medicine.