Scholarlink

<p>The aim of this study was to determine the impact of myostatin deficiency on the mechanical and contractile adaptations of the soleus muscle to functional overload (FO). Using a cross-sectional design, we compared the control and FO soleus muscles of myostatin-deficient (BEH<sup>cc</sup>) and myostatin-functional (BEH⁺⁺) mice. FO was induced by 28 days of gastrocnemius ablation. Soleus muscles were isolated and subjected to an isometric-eccentric contraction protocol to analyse contractile performance and tissue mechanical behaviour. FO significantly increased muscle mass, tetanic force, and stiffness, in BEH⁺⁺ mice (<i>p</i> &lt; 0.05), but not in BEH<sup>cc</sup> where absolute force was even reduced (<i>p</i> &lt; 0.05). These findings indicate that myostatin plays an important role in successful skeletal muscle adaptations and preservation of muscle function under chronic loading.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Myostatin deficiency blunts mechanical adaptation of soleus muscle to overload

  • 期刊论文

  • 发表日期：

    2025年11月3日

查看全文
  • Leonardo Cesanelli,
  • P. Minderis,
  • A. Fokin,
  • A. Ratkevicius,
  • D. Satkunskiene,
  • H. Degens

摘要

The aim of this study was to determine the impact of myostatin deficiency on the mechanical and contractile adaptations of the soleus muscle to functional overload (FO). Using a cross-sectional design, we compared the control and FO soleus muscles of myostatin-deficient (BEHcc) and myostatin-functional (BEH⁺⁺) mice. FO was induced by 28 days of gastrocnemius ablation. Soleus muscles were isolated and subjected to an isometric-eccentric contraction protocol to analyse contractile performance and tissue mechanical behaviour. FO significantly increased muscle mass, tetanic force, and stiffness, in BEH⁺⁺ mice (p < 0.05), but not in BEHcc where absolute force was even reduced (p < 0.05). These findings indicate that myostatin plays an important role in successful skeletal muscle adaptations and preservation of muscle function under chronic loading.