<p>This report introduces a novel twin-corrugated twisted tape (TC-TT) insert designed to enhance heat transfer in exchanger tubes. The key innovation lies in the twin-corrugated structure, which generates a twin-swirl flow effect. The corrugated surface synergistically increases flow disturbance and expands the effective heat transfer area. The studied parameters were twist ratios (<i>y/w</i> = 3.0, 3.5, and 4.0) and corrugation angles (<i>θ</i> = 45°, 60°, 75°, and 90°) at 6,000 ≤ Re ≤ 20,000. The results show that using twin-corrugated twisted tapes increases the average Nusselt number by roughly 60–135% compared to a plain tube and by 16–35% compared to a conventional single-twisted tape, confirming the effectiveness of this structural modification. This enhancement is primarily due to the combination of double swirling-flows and enhanced effective heat transfer generated by the corrugated surface. Reducing the corrugation angle (<i>θ</i>) and twist ratio (<i>y</i>/<i>w</i>) led to increases in the Nusselt number (Nu), friction factor (<i>f</i>), and thermal performance factor (TPF). Within the studied range, the Nusselt number, friction factor, and thermal performance factor reached maximum values of 5.18, 0.153, and 1.44, respectively, at a twist ratio of 3.0, a corrugation angle of 45°, and Re = 6,000. Regression analysis was utilized to develop correlations for the Nu and <i>f</i>, considering the Re, Pr, <i>y</i>/<i>w</i>, and <i>θ</i> as influencing variables. The proposed correlations for predicting the friction factor and Nusselt number have errors within ±3% and ±2%, respectively. In addition, an artificial neural network (ANN) was developed for predicting the thermal performance values occurring below the experimental study range. The optimal state ANN model shows remarkable prediction accuracy with <i>R</i>² of 0.965.</p>