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<p>Starches obtained from Assam glutinous&#xa0; rice exhibited&#xa0; distinct physiochemical properties and behaviors. In this research work, the protective action of Assam glutinous rice starches was observed on degradation of levothyroxine. The interplay between amylose content, thermal properties &amp;&#xa0; thermodynamic behaviors, and their&#xa0;protective potential on levothyroxine degradation was studied using Differential Scanning Calorimeter (DSC) and Isothermal titration calorimetry (ITC), and levothyroxine degradation was counted using the validated LC–MS/MS method. Nevertheless, amylose content, gelatinization peak temperature, and gelatinization enthalpy were not sufficient to define correlation for protective behavior; however, reaction enthalpy (∆H) and entropy (T∆S) shown a moderate-to-strong correlation to define the protective action of starches on levothyroxine degradation over accelerated stability period (40 ± 2&#xa0;°C and 75 ± 5% RH; 90&#xa0;days). The binding isotherm indicated formation of a stable complex or other ordered structures with pigmented rice starches, with the reduction in entropy reflecting the decrease in molecular freedom and increased order upon binding. An initial (pre saturation) steep isotherm reflected active binding interactions whereas, final region had shown plateau phase for starches which comparatively higher protective potential over levothyroxine degradation. The individual parameter was not adequate to justify the correlation between properties and protective potential. The associations between various properties of glutinous rice starch and levothyroxine were studied using deep machine learning multilayer perceptron model. The 9:5:2 artificial neural network (ANN) model elaborated reaction entropy and enthalpy as the most important variables to define the protective action of Assam glutinous rice starches on levothyroxine degradation.</p>

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A thermodynamic explanation to understand protective effect of Assam glutinous rice starch on levothyroxine degradation

  • 期刊论文

  • 发表日期：

    2025年11月5日

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  • Prajyot R. Sonane,
  • Pavan kumar Sathala,
  • Mahesh Rathod,
  • Laltanpuii Chenkaul,
  • Dimple S. Lalchandani,
  • Atul Dewangan,
  • Pawan Kumar Porwal

摘要

Starches obtained from Assam glutinous  rice exhibited  distinct physiochemical properties and behaviors. In this research work, the protective action of Assam glutinous rice starches was observed on degradation of levothyroxine. The interplay between amylose content, thermal properties &  thermodynamic behaviors, and their protective potential on levothyroxine degradation was studied using Differential Scanning Calorimeter (DSC) and Isothermal titration calorimetry (ITC), and levothyroxine degradation was counted using the validated LC–MS/MS method. Nevertheless, amylose content, gelatinization peak temperature, and gelatinization enthalpy were not sufficient to define correlation for protective behavior; however, reaction enthalpy (∆H) and entropy (T∆S) shown a moderate-to-strong correlation to define the protective action of starches on levothyroxine degradation over accelerated stability period (40 ± 2 °C and 75 ± 5% RH; 90 days). The binding isotherm indicated formation of a stable complex or other ordered structures with pigmented rice starches, with the reduction in entropy reflecting the decrease in molecular freedom and increased order upon binding. An initial (pre saturation) steep isotherm reflected active binding interactions whereas, final region had shown plateau phase for starches which comparatively higher protective potential over levothyroxine degradation. The individual parameter was not adequate to justify the correlation between properties and protective potential. The associations between various properties of glutinous rice starch and levothyroxine were studied using deep machine learning multilayer perceptron model. The 9:5:2 artificial neural network (ANN) model elaborated reaction entropy and enthalpy as the most important variables to define the protective action of Assam glutinous rice starches on levothyroxine degradation.