<p>This study explores the role of blood-based pentameric hybrid nanofluids composed of iron oxide, aluminum oxide, silver, gold, and copper, when circulated between two disks, in drug delivery applications. These hybrid nanofluids hold tremendous potential due to their unique properties, particularly in the presence of an external magnetic field and thermal radiation, for controlled drug release, targeted delivery capabilities, and synergistic chemical interactions. The development of drug delivery systems can be supported by mathematical modeling. This approach reduces the need for expensive laboratory experiments by deepening the understanding of the physicochemical mechanisms of drug transport. The Oldroyd-B fluid model is used to understand the mathematical behavior of blood flow under thermal conductivity and heat generation variables. The Darcy–Forchheimer model is applied to represent porous media, taking into account porosity and permeability variables. Graphical analysis reveals that relaxation time, nanoparticle concentration, and magnetic field parameters enhance the velocity pattern near the lower disk but reduce the temperature distribution. Furthermore, higher heat generation coefficient values were found to result in higher temperatures. Improvements in the surface friction coefficient and Nusselt number were observed with increasing magnetic field strength, allowing for precise drug release at the desired location and time in response to magnetic stimulation. The pentagonal nanofluids also demonstrated their ability to maintain near-surface temperatures, which in turn regulates blood flow. The accuracy of the numerical results demonstrates the effective contribution of pentagonal nanofluids to drug delivery systems, enhancing performance by improving thermal and chemical properties.</p>