<p>Microchannel heat sinks (MCHSs) are effective and compact thermal management devices that are broadly developed in recent years. Performance of these equipment is impacted by a variety of the factors that have been investigated and evaluated by the scholars and researches. Use of coolant with improved thermal properties can elevate heat transfer rate and consequently the thermal performance. One of the attractive techniques for improvement of convective heat transfer is use of nanofluids, with higher thermal conductivity in comparison with the conventional heat transfer fluid, as the coolant. The aim of the current article is to comprehensively review the applications of the hybrid nanofluids, containing more than single nanomaterial in the base fluid, in the MCHSs. Findings of the research works on the use of these nanofluids in MCHSs have revealed considerable potential for elevation in heat transfer rate. Several factors impact the modification of heat transfer in MCHSs with hybrid nanofluids including the characteristics of the coolant, configuration of the system and operating conditions. As well as heat transfer, other factors such as the pressure drop and entropy generation would be impacted due to the existence of the hybrid nanomaterials in the working fluid. Some recommendations are presented in this article for the forthcoming researches in order to further enhance the heat transfer and modify the characteristics of these systems.</p>