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<p>Small fiber neuropathies (SFN) are a group of diseases that affect finely myelinated fibers and unmyelinated C fibers and can result in pain, temperature sensitivity and altered sensations, as well as have an impact on sweating due to its effect on the nerves responsible for regulating of sweat glands. Its evaluation requires the use of auxiliary tests in addition to the conventional neurophysiologic techniques that can be uncomfortable and invasive. Moreover, current tests are time-consuming, expensive and often require the use of specialist equipment. Therefore, the objective of this study was to develop a faster, more cost-effective test using a sodium alginate (SA) polymeric membrane containing alizarin red (AR) and sodium carbonate (SC) to diagnose SFN in patients with diabetes. Thermal analysis demonstrated an interaction of the AR and SC with the SA, enabling the formation of polymeric membranes. The swelling test showed the membrane's capacity to react with sweat and enable a colorimetric reaction. Fourier transform infrared spectroscopy (FTIR) analysis showed changes in the absorption bands of the membranes after the colorimetric reaction. A hen's egg-chorioallantoic membrane (HET-CAM) assay demonstrated that the membranes have no potential for skin irritation. Therefore, the membranes, which are biodegradable, inexpensive and easy to apply, represent a promising development in respect of a new technology to aid in the diagnosis of small fiber neuropathies.</p>

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Development and evaluation of a rapid dermic adhesive test containing alizarine red and sodium carbonate for the diagnosis of diabetic neuropathy

  • 期刊论文

  • 发表日期：

    2025年5月11日

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  • Maria Joseli Melo de Jesus,
  • Bruno dos Santos Lima,
  • Déborah Danielle Tertuliano Marinho e Albuquerque,
  • Nicole Menezes Pinto,
  • Bárbara dos Santos Soares,
  • Dayanne Valéria Soares Prado,
  • Igor Araújo Santos,
  • Fabiana da Silva Castro,
  • Eduardo Luis de Aquino Neves,
  • Mairim Russo Serafini,
  • Adriano Antunes de Souza Araújo

摘要

Small fiber neuropathies (SFN) are a group of diseases that affect finely myelinated fibers and unmyelinated C fibers and can result in pain, temperature sensitivity and altered sensations, as well as have an impact on sweating due to its effect on the nerves responsible for regulating of sweat glands. Its evaluation requires the use of auxiliary tests in addition to the conventional neurophysiologic techniques that can be uncomfortable and invasive. Moreover, current tests are time-consuming, expensive and often require the use of specialist equipment. Therefore, the objective of this study was to develop a faster, more cost-effective test using a sodium alginate (SA) polymeric membrane containing alizarin red (AR) and sodium carbonate (SC) to diagnose SFN in patients with diabetes. Thermal analysis demonstrated an interaction of the AR and SC with the SA, enabling the formation of polymeric membranes. The swelling test showed the membrane's capacity to react with sweat and enable a colorimetric reaction. Fourier transform infrared spectroscopy (FTIR) analysis showed changes in the absorption bands of the membranes after the colorimetric reaction. A hen's egg-chorioallantoic membrane (HET-CAM) assay demonstrated that the membranes have no potential for skin irritation. Therefore, the membranes, which are biodegradable, inexpensive and easy to apply, represent a promising development in respect of a new technology to aid in the diagnosis of small fiber neuropathies.