<p>Magnesium (Mg) based implants are acquiring fame in biomedical fields, particularly where biodegradable materials are desired to eradicate the need for a second surgery. The materials are employed for short-term implants, especially in orthopedics and cardiovascular stents, as they can reduce hospitalization time and associated expenses. From a material standpoint, their lightweight, high strength-to-weight ratio, ease of manufacture, excellent biocompatibility, and biodegradability offer distinct advantages, making them suitable for temporary implants. Nonetheless, their primary challenge stems from their susceptibility to corrosion within physiological environments. This work reported silica (Si) and silica-hyaluronic acid (Si/HA) coating on AZ31 Mg alloy that enhances corrosion resistance and biocompatibility. The Si/HA-coated substrate demonstrated a three-dimensional porous structure, resulting in an intermediate degradation rate, higher than the Si-coated substrate and lower than the uncoated substrate. The amino acids of HA induced a biomineralized layer facilitating a significant hike rate of calcium and phosphate ions, forming a halloysite-like structure. The hemocompatibility and cell adhesion were supported by Si/HA-coated substrate along with effective bacterial inhibition. On the whole, Si/HA-coated Mg substrate can be employed in healthcare applications where biodegradability and biological performance are vital.</p><p></p>