<p>A popular natural sweetener with a long history of ethnomedical uses dating back to ancient civilizations, honey is a viscous liquid with an amber tint noted for its abundance of bioactive components. This investigation used a honey solution containing bioactive phytoconstituents to create bismuth vanadate nanoparticles (BiVO₄ NPs) for the first time. XRD, UV-Vis, FTIR, TEM, SAED pattern, SEM, EDX mapping, XPS, EIS, and BET studies highlighted the physicochemical features of as-prepared BiVO₄ NPs. XRD verified the biogenic synthesis of NPs, demonstrating a monoclinic scheelite structure with single-phase purity in the produced material. FTIR peaks at 1315 cm^‒1 and 1148 cm^‒1 indicate protein structures in the green source-mediated BiVO₄ NPs. Biosynthesized BiVO₄ NPs exhibit a quasi-spherical morphology with a median particle size of 25.74 nm. Moreover, the photocatalytic efficacy was disclosed by assessing the degradation rate of metronidazole, and various parameters influencing catalytic performance were investigated to attain maximum degradation efficiency. In a mere forty minutes, honey-mediated BiVO₄ NPs demonstrated substantial degradation of the metronidazole drug under solar light, accomplished an optimal degradation of 71.04% under the reaction conditions of 0.4 mL H₂O₂, 0.5 g/L catalyst, and 10 mg/L metronidazole concentration. Furthermore, the scavenging test was used to identify the radicals implicated in metronidazole degradation in the presence of a BiVO₄ photocatalyst. This study indicates that BiVO₄ NPs have significant potential for ecological restoration using photocatalysis.</p> Graphical Abstract <p></p>