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<p>In this study, we prepared Ni<sub>0.2</sub>Co<sub>0.8</sub>Fe<sub>2</sub>O<sub>4</sub> encapsulated within niosome as a nanocarrier for the delivery of epirubicin (EPI) into breast cancer cells. Here, magnetic Ni<sub>0.2</sub>Co<sub>0.8</sub>Fe<sub>2</sub>O<sub>4</sub> was coated by poly (ethylene oxide), and modified via treatment with sulfuric acid. By a niosomal at its outer layer, EPI loaded into the niosomal layer, and due to this layer, the carrier (EPI+Nano) demonstrated a pH-dependent release that can be effective for cancer treatment. MCF-7 cells showed a 38% increase in cytotoxicity and apoptosis, this increase was more than the other two groups (EPI: 26% and Nano: 21%), suggesting the superiority of the carrier (EPI+Nano). Following adjustment for the expression levels of the genes, cytotoxicity was observed in breast cancer cells; the carrier (EPI+Nano) led to down-regulation of the MMP-2 and MMP-9 genes and up-regulation of the caspase-3 and caspase-9 genes. The carrier (EPI+Nano) also caused an inhibitory effect on the migration of MCF-7 cells, which was significantly higher than EPI and Nano. Also, all the mentioned treatments significantly increased the levels of reactive oxygen species.</p> Graphical Abstract <p></p>

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Preparation and in-vitro evaluation of epirubicin-loaded Ni0.2Co0.8Fe2O4@PEO-SO3H@niosome nanocarrier for breast cancer treatment

  • 期刊论文

  • 发表日期：

    2025年6月12日

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  • Faten Eshrati Yeganeh,
  • Mojtaba Azizi

摘要

In this study, we prepared Ni0.2Co0.8Fe2O4 encapsulated within niosome as a nanocarrier for the delivery of epirubicin (EPI) into breast cancer cells. Here, magnetic Ni0.2Co0.8Fe2O4 was coated by poly (ethylene oxide), and modified via treatment with sulfuric acid. By a niosomal at its outer layer, EPI loaded into the niosomal layer, and due to this layer, the carrier (EPI+Nano) demonstrated a pH-dependent release that can be effective for cancer treatment. MCF-7 cells showed a 38% increase in cytotoxicity and apoptosis, this increase was more than the other two groups (EPI: 26% and Nano: 21%), suggesting the superiority of the carrier (EPI+Nano). Following adjustment for the expression levels of the genes, cytotoxicity was observed in breast cancer cells; the carrier (EPI+Nano) led to down-regulation of the MMP-2 and MMP-9 genes and up-regulation of the caspase-3 and caspase-9 genes. The carrier (EPI+Nano) also caused an inhibitory effect on the migration of MCF-7 cells, which was significantly higher than EPI and Nano. Also, all the mentioned treatments significantly increased the levels of reactive oxygen species.

Graphical Abstract