<p>Osteopenia is a prevailing bone disorder characterized by lower-than-normal bone density that escalates the risk of fracture. Titanium and its alloys are cornerstone materials valued for their excellent mechanical and biological compatibility. The bio-inertness of titanium stops its integration with the bone. This incompetency curbs its congruence with the bone which can be rectified with surface modification. This study focuses on crafting titanium with europium-doped bioglass to enhance its biological functionality. The intercalated doped ions in the bioglass can boost bone formation and integration with the implant. The europium-doped bioglass was evenly coated on the titanium surface (EB-Ti). The functional groups of EB-Ti confirmed that the surface was modified with moieties of europium-doped bioglass coating. The crystalline nature of the EB-Ti was contributed by combeite, sodium calcium silicate, whitelock and wollastonite phases. The europium-doped bioglass coating acts as a passive layer on the titanium substrate thereby influencing the depletion rate. The progression of biomineral accumulation on the EB-Ti surface confirmed their bioactivity. The filopodial extensions and flattenings of the MG63 cells on the EB-Ti clearly indicated cell adhesion on the implant surface.</p> Graphical Abstract <p></p>

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Tailored bioactive glass coating on titanium implants to elevate bioactivity and longevity

  • Saranya Kannan,
  • Pugalmani Sivashanmugam,
  • Chitra Shivalingam,
  • Palvannan Thayumanavan

摘要

Osteopenia is a prevailing bone disorder characterized by lower-than-normal bone density that escalates the risk of fracture. Titanium and its alloys are cornerstone materials valued for their excellent mechanical and biological compatibility. The bio-inertness of titanium stops its integration with the bone. This incompetency curbs its congruence with the bone which can be rectified with surface modification. This study focuses on crafting titanium with europium-doped bioglass to enhance its biological functionality. The intercalated doped ions in the bioglass can boost bone formation and integration with the implant. The europium-doped bioglass was evenly coated on the titanium surface (EB-Ti). The functional groups of EB-Ti confirmed that the surface was modified with moieties of europium-doped bioglass coating. The crystalline nature of the EB-Ti was contributed by combeite, sodium calcium silicate, whitelock and wollastonite phases. The europium-doped bioglass coating acts as a passive layer on the titanium substrate thereby influencing the depletion rate. The progression of biomineral accumulation on the EB-Ti surface confirmed their bioactivity. The filopodial extensions and flattenings of the MG63 cells on the EB-Ti clearly indicated cell adhesion on the implant surface.

Graphical Abstract