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<p>This study focuses on the synthesis of molybdenum disulfide (MoS<sub>2</sub>) nanosheets through a straightforward hydrothermal process, followed by their decoration with silver (Ag) nanoparticles using ammonia (NH<sub>3</sub>) and glucose (C<sub>6</sub>H<sub>12</sub>O<sub>6</sub>). The resulting nanocomposite was thoroughly characterized using various analytical techniques, including XRD, Raman spectroscopy, TEM, HR-TEM, FE-SEM, EDX, element mapping, XPS, AFM, and BET analysis. The antimicrobial efficacy of the Ag&amp;MoS<sub>2</sub> nanocomposite (0D/2D) was evaluated using MIC, MBC, and disk diffusion susceptibility assays in comparison to the antibiotic ampicillin. Notably, the Ag&amp;MoS<sub>2</sub> combination demonstrated significant antibacterial activity against Gram-negative bacteria. Specifically, <i>Escherichia coli</i> exhibited the highest efficacy with a 73.02% reduction, while <i>Streptococcus mutans</i> showed the lowest efficacy at 0.05%, primarily due to the physical damage generated by the nanocomposite.</p> Graphical Abstract <p></p>

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The application of molybdenum disulfide nanosheets decorated with silver nanoparticles for antibacterial activity

  • 期刊论文

  • 发表日期：

    2025年2月17日

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  • Laleh Sayad Arbabi,
  • Majid Azarang,
  • M. Sookhakian,
  • Wan Jefrey Basirun

摘要

This study focuses on the synthesis of molybdenum disulfide (MoS2) nanosheets through a straightforward hydrothermal process, followed by their decoration with silver (Ag) nanoparticles using ammonia (NH3) and glucose (C6H12O6). The resulting nanocomposite was thoroughly characterized using various analytical techniques, including XRD, Raman spectroscopy, TEM, HR-TEM, FE-SEM, EDX, element mapping, XPS, AFM, and BET analysis. The antimicrobial efficacy of the Ag&MoS2 nanocomposite (0D/2D) was evaluated using MIC, MBC, and disk diffusion susceptibility assays in comparison to the antibiotic ampicillin. Notably, the Ag&MoS2 combination demonstrated significant antibacterial activity against Gram-negative bacteria. Specifically, Escherichia coli exhibited the highest efficacy with a 73.02% reduction, while Streptococcus mutans showed the lowest efficacy at 0.05%, primarily due to the physical damage generated by the nanocomposite.

Graphical Abstract