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<p>Biomedical science, nowadays, benefits from ferromagnetic nanoparticles for diverse applications. Ferrites are a group of promising materials whose properties can be modified by changing synthesis parameters, doping, and coating to make them suitable for biomedical applications, like drug delivery. In this study, Dy-doped Mn-Zn ferrite (DMZF) nanoparticles were synthesized using a self-combustion sol-gel method and subsequently coated with chitosan (CS). Further polyethylene glycol (PEG) coating was conducted to increase their stability. In order to characterize and investigate the properties of coated DMZF nanoparticles, X-ray diffraction (XRD) with Rietveld refinement, transmission electron microscopy (TEM) and field emission scanning electron microscopy (FE-SEM), thermogravimetric and differential thermal analysis (TG-DTA), Fourier-transform infrared spectroscopy (FTIR), and vibrating sample magnetometer (VSM) analyses were performed. Dynamic light scattering (DLS), zeta potential, and UV-visible spectroscopy were also conducted to estimate the practicality of the nanocarriers. Based on the results obtained, the nanoparticles coated at a 1:1:1 mass ratio of particle: chitosan: glutaraldehyde (as a crosslinker) exhibited a notable performance with high saturation magnetization (~57 emu/g), high zeta potential value (~ −24 mV), and hydrodynamic size of ~460 nm. The oxaliplatin loading on the CS- and PEG-CS-coated nanoparticles was 48% after 48 h. 35% of the loaded drug on the PEG-CS-coated DMZF was released at an acidic pH of 5.5 during 24 h. The corresponding amount for the CS-coated DMZF was 68%.</p> Graphical Abstract <p></p>

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Oxaliplatin delivery by sol-gel synthesized polymer-coated Dy-doped Mn-Zn ferrite nanocarriers

  • 期刊论文

  • 发表日期：

    2025年2月6日

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  • Saeedeh Shahedi,
  • Zahra Daneshfar,
  • Saeed Hasani,
  • Seyedeh Mansoureh Hashemi,
  • Alireza Mashreghi

摘要

Biomedical science, nowadays, benefits from ferromagnetic nanoparticles for diverse applications. Ferrites are a group of promising materials whose properties can be modified by changing synthesis parameters, doping, and coating to make them suitable for biomedical applications, like drug delivery. In this study, Dy-doped Mn-Zn ferrite (DMZF) nanoparticles were synthesized using a self-combustion sol-gel method and subsequently coated with chitosan (CS). Further polyethylene glycol (PEG) coating was conducted to increase their stability. In order to characterize and investigate the properties of coated DMZF nanoparticles, X-ray diffraction (XRD) with Rietveld refinement, transmission electron microscopy (TEM) and field emission scanning electron microscopy (FE-SEM), thermogravimetric and differential thermal analysis (TG-DTA), Fourier-transform infrared spectroscopy (FTIR), and vibrating sample magnetometer (VSM) analyses were performed. Dynamic light scattering (DLS), zeta potential, and UV-visible spectroscopy were also conducted to estimate the practicality of the nanocarriers. Based on the results obtained, the nanoparticles coated at a 1:1:1 mass ratio of particle: chitosan: glutaraldehyde (as a crosslinker) exhibited a notable performance with high saturation magnetization (~57 emu/g), high zeta potential value (~ −24 mV), and hydrodynamic size of ~460 nm. The oxaliplatin loading on the CS- and PEG-CS-coated nanoparticles was 48% after 48 h. 35% of the loaded drug on the PEG-CS-coated DMZF was released at an acidic pH of 5.5 during 24 h. The corresponding amount for the CS-coated DMZF was 68%.

Graphical Abstract