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<p><sup>64</sup>Cu is a radioactive isotope used in positron emission tomography (PET) imaging, with promising applications in theranostics. However, the supply of <sup>64</sup>Cu is limited and requires significant personnel involvement. To enhance <sup>64</sup>Cu yield and minimize personnel exposure, we presented an automated method for producing high-specific-activity <sup>64</sup>Cu. Our approach involved the design of a novel electroplating device that employed <sup>64</sup>Ni as the target material, coupled with an automated system for target dissolution and transfer. Automated ion exchange chromatography was utilized to efficiently purify the dissolved <sup>64</sup>Cu, achieving a radionuclide purity of 99.9%. We utilized enriched <sup>64</sup>Ni (99.32%) and achieved an electroplating thickness of 60.2–62.2&#xa0;mg/cm<sup>2</sup>, resulting in a radioactive yield of over 300&#xa0;mCi. Further synthesis of <sup>64</sup>Cu-NOTA-Nectin-4 was carried out, and it was applied to the imaging and biological distribution studies of esophageal squamous cell carcinoma, effectively targeting the tumor site. Leveraging the moderate half-life of <sup>64</sup>Cu and its production via medical cyclotrons, this approach enables extended imaging windows, precise tumor localization, providing new insights for the early diagnosis of esophageal cancer in clinical practice.</p>

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Efficient preparation of 64Cu and radiolabeling of Nectin-4 antibody for esophageal cancer imaging

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月29日

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  • Xin Di,
  • Xilian Wang,
  • Zihao Wang,
  • Xinyun Ge,
  • Shuyu Lin,
  • Jiaqiang Hou,
  • Yan Yang,
  • Zhi Yang,
  • Zhou Lu,
  • Fubo Ye,
  • Ruiling Xu,
  • Xiaoan Li

摘要

64Cu is a radioactive isotope used in positron emission tomography (PET) imaging, with promising applications in theranostics. However, the supply of 64Cu is limited and requires significant personnel involvement. To enhance 64Cu yield and minimize personnel exposure, we presented an automated method for producing high-specific-activity 64Cu. Our approach involved the design of a novel electroplating device that employed 64Ni as the target material, coupled with an automated system for target dissolution and transfer. Automated ion exchange chromatography was utilized to efficiently purify the dissolved 64Cu, achieving a radionuclide purity of 99.9%. We utilized enriched 64Ni (99.32%) and achieved an electroplating thickness of 60.2–62.2 mg/cm2, resulting in a radioactive yield of over 300 mCi. Further synthesis of 64Cu-NOTA-Nectin-4 was carried out, and it was applied to the imaging and biological distribution studies of esophageal squamous cell carcinoma, effectively targeting the tumor site. Leveraging the moderate half-life of 64Cu and its production via medical cyclotrons, this approach enables extended imaging windows, precise tumor localization, providing new insights for the early diagnosis of esophageal cancer in clinical practice.