Optimising the number of measurements for absorbed dose-to-water calibration coefficient of ionization chamber by cross-calibration using high-energy electron beams
摘要
This study aimed to improve workflow efficiency in absorbed dose-to-water cross-calibration using high-energy electron beams. The AAPM TG-51 and TG-198 protocols emphasise accurate dosimeter calibration, typically involving labour-intensive, two-system measurements. To streamline this process, a statistical method was applied to determine the optimal number of repeated measurements required. Absorbed dose measurements were performed using a 16-MeV electron beam with a Farmer-type ionisation chamber and a parallel-plate chamber. Three series of 10 repeated measurements were analysed using the coefficient of variation, relative error, and probability-based assessments. Results showed that five or more measurements resulted in calibration coefficient variations within acceptable limits and that additional repetitions did not enhance accuracy. This study revealed a method for deriving the appropriate relationship between uncertainty and the minimum number of measurements required for the measuring instruments owned by a facility., with a reduced working time and minimised risk of human error. This approach enables facilities to tailor quality assurance protocols to their specific equipment while maintaining both measurement precision and operational efficiency.