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<p>This study evaluated the pharmacokinetics and tissue depletion of oxytetracycline (OTC) in broiler chickens. Forty-two birds were assigned to two treated groups and one control; OTC was administered intramuscularly at 20&#xa0;mg/kg for three days or as a single radiolabeled [<sup>3</sup>H] OTC dose. Tissue samples collected up to 168&#xa0;h were analysed via ELISA (IC<sub>20</sub>: 0.05&#xa0;ppb; IC<sub>50</sub>: 0.22&#xa0;ppb). Peak residues (&gt; 250&#xa0;ppb) occurred within 48&#xa0;h in kidney, intestine, liver and muscles, declining markedly by 120–144&#xa0;h. Radiotracer studies confirmed depletion patterns. Health risk assessment indicated that 12.5% of samples exceeded safe exposure limits, highlighting potential dietary risks.</p>

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Depletion of oxytetracycline in broiler chickens using radiolabeled [3H] and non-labeled drug formulations and subsequent assessment of dietary risks to consumers

  • 期刊论文

  • 发表日期：

    2026年4月2日

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  • Muhammad Ismail Chughtai,
  • James Jacob. Sasanya,
  • Uzma Maqbool,
  • Muhammad Salah-ud-Din Shah,
  • Beom Su Jang,
  • Muhammad Yasin

摘要

This study evaluated the pharmacokinetics and tissue depletion of oxytetracycline (OTC) in broiler chickens. Forty-two birds were assigned to two treated groups and one control; OTC was administered intramuscularly at 20 mg/kg for three days or as a single radiolabeled [3H] OTC dose. Tissue samples collected up to 168 h were analysed via ELISA (IC20: 0.05 ppb; IC50: 0.22 ppb). Peak residues (> 250 ppb) occurred within 48 h in kidney, intestine, liver and muscles, declining markedly by 120–144 h. Radiotracer studies confirmed depletion patterns. Health risk assessment indicated that 12.5% of samples exceeded safe exposure limits, highlighting potential dietary risks.