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<p>Iridium-192 is a crucial radionuclide, extensively used in brachytherapy for cancer treatment. The accurate estimation of the production rate of <sup>192</sup>Ir is critical for optimizing the manufacture of brachytherapy sources in nuclear reactors and ensuring their dosimetric quality. A rigorous calculation of this rate makes it possible to define irradiation times, guarantee the activity required at the clinical moment, and reduce variations in production, all of which have a direct impact on therapeutic efficacy. This study evaluates the production rate of <sup>192</sup>Ir in wires composed of natural iridium-platinum alloys when irradiated in research reactors. The methodology incorporates the Hϕgdhal convention, taking into account neutron flux distribution, cross-section data, self-shielding factor, and resonance integral estimations. Experimental validation is carried out through neutron activation analysis and gamma spectroscopy using a HPGe detector. The results demonstrate a strong correlation between theoretical calculations and experimental measurements, providing a reliable framework for optimizing <sup>192</sup>Ir production.</p>

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Validation of the estimation of 192Ir production rates in wires from natural iridium-platinum in research reactors

  • 期刊论文

  • 发表日期：

    2026年4月2日

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  • P. Tataje,
  • B. Ticona,
  • S. Daza,
  • Anais Adauto

摘要

Iridium-192 is a crucial radionuclide, extensively used in brachytherapy for cancer treatment. The accurate estimation of the production rate of 192Ir is critical for optimizing the manufacture of brachytherapy sources in nuclear reactors and ensuring their dosimetric quality. A rigorous calculation of this rate makes it possible to define irradiation times, guarantee the activity required at the clinical moment, and reduce variations in production, all of which have a direct impact on therapeutic efficacy. This study evaluates the production rate of 192Ir in wires composed of natural iridium-platinum alloys when irradiated in research reactors. The methodology incorporates the Hϕgdhal convention, taking into account neutron flux distribution, cross-section data, self-shielding factor, and resonance integral estimations. Experimental validation is carried out through neutron activation analysis and gamma spectroscopy using a HPGe detector. The results demonstrate a strong correlation between theoretical calculations and experimental measurements, providing a reliable framework for optimizing 192Ir production.