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<p>Smart silver nanocomposite hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), were developed using one-step and two-step radiolytic synthesis methods. In the latter, P(HEMA/IA) hydrogels were synthesized by gamma radiation, and subsequently used as a matrix for the formation of silver nanoparticles (AgNPs), whereas the one-step method involves the formation of Ag/P(HEMA/IA) nanocomposites in a single step. The results showed that Ag/P(HEMA/IA) exhibited strong antimicrobial activity. Importantly, the one-step synthesis combines fabrication and sterilization, reducing both production time and costs. Together, these advantages establish the one-step method as an efficient approach to producing antimicrobial hydrogels for wound dressings.</p>

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Smart Ag/P(HEMA/IA) nanocomposite hydrogels for wound dressing obtained by different radiation approaches

  • 期刊论文

  • 发表日期：

    2026年2月14日

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  • Maja Krstic,
  • Zorana Rogic Miladinovic,
  • Ivanka Stanimirovic,
  • Zdravko Stanimirovic,
  • Dusko Dudic,
  • Slobodanka Galovic,
  • Edin Suljovrujic

摘要

Smart silver nanocomposite hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), were developed using one-step and two-step radiolytic synthesis methods. In the latter, P(HEMA/IA) hydrogels were synthesized by gamma radiation, and subsequently used as a matrix for the formation of silver nanoparticles (AgNPs), whereas the one-step method involves the formation of Ag/P(HEMA/IA) nanocomposites in a single step. The results showed that Ag/P(HEMA/IA) exhibited strong antimicrobial activity. Importantly, the one-step synthesis combines fabrication and sterilization, reducing both production time and costs. Together, these advantages establish the one-step method as an efficient approach to producing antimicrobial hydrogels for wound dressings.