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<p>This study presents physiological responses and extracranial radiation exposure in patients undergoing Gamma Knife Radiosurgery using a practical, cost-effective, direct-reading novel dosimeter. Biochemical changes were assessed in two dose groups and radiation doses to body organs were quantified. High-dose treatment induced significant (<i>p</i> ≤ 0.05) hepatic stress and lipid metabolism alterations, with dose dependent changes across multiple organ systems. Extracranial organs received 0.001–0.017% of prescribed dose, with neck and chest regions most exposed. Larger collimators produced greater scattered radiation. This study uniquely combines scatter radiation dosimetry with comprehensive biochemical monitoring, revealing measurable systemic effects requiring enhanced protection protocols for patients undergoing Gamma Knife treatments to minimize secondary radiation risks.</p>

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Comparative analysis of biochemical marker responses and extracranial dose measurements in low and high dose 60Co gamma knife radiosurgery

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Bazhdar N. Mohammed,
  • Asaad H. Ismail,
  • Edrees M. Tahir,
  • Hoshanc S. Rashid

摘要

This study presents physiological responses and extracranial radiation exposure in patients undergoing Gamma Knife Radiosurgery using a practical, cost-effective, direct-reading novel dosimeter. Biochemical changes were assessed in two dose groups and radiation doses to body organs were quantified. High-dose treatment induced significant (p ≤ 0.05) hepatic stress and lipid metabolism alterations, with dose dependent changes across multiple organ systems. Extracranial organs received 0.001–0.017% of prescribed dose, with neck and chest regions most exposed. Larger collimators produced greater scattered radiation. This study uniquely combines scatter radiation dosimetry with comprehensive biochemical monitoring, revealing measurable systemic effects requiring enhanced protection protocols for patients undergoing Gamma Knife treatments to minimize secondary radiation risks.