Scholarlink

<p>Inductively coupled plasma–mass spectrometry (ICP-MS) is subject to several noise sources that are unique among mass spectrometry systems. These noise terms can be modeled in fully-calibrated measurement routine simulations to predict, quantify, and address major uncertainty sources for optimizing isotope ratio determinations. This work 1) highlights the minimal contribution of intrinsic uncertainties when calibrating with a certified reference material, and 2) emphasizes the critical role of noise mitigation in non-traceable measurement regimes. The approach detailed here is applicable to other detector and source configurations, providing a valuable framework for improving precision in mass spectrometric analyses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

First principles modeling of precision and traceability in ICP-MS analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月25日

查看全文
  • Shelby Bowden,
  • Kyle M. Samperton

摘要

Inductively coupled plasma–mass spectrometry (ICP-MS) is subject to several noise sources that are unique among mass spectrometry systems. These noise terms can be modeled in fully-calibrated measurement routine simulations to predict, quantify, and address major uncertainty sources for optimizing isotope ratio determinations. This work 1) highlights the minimal contribution of intrinsic uncertainties when calibrating with a certified reference material, and 2) emphasizes the critical role of noise mitigation in non-traceable measurement regimes. The approach detailed here is applicable to other detector and source configurations, providing a valuable framework for improving precision in mass spectrometric analyses.