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<p>Cancer remains a major cause of mortality, necessitating the exploration of novel therapeutic and diagnostic strategies. Quercetin is known for its antioxidant properties that may counteract carcinogenesis by neutralising free radicals. Therefore, it might be suitable to be used as a radiotracer. This study aimed to evaluate the biodistribution of technetium-99m-labelled quercetin ([<sup>99m</sup>Tc]Tc-quercetin) in a carcinogen-induced colorectal cancer murine model. Quercetin was successfully radiolabelled with technetium-99m, achieving a high radiochemical yield. The radiolabelled compound was then administered to tumour-bearing mice, and its biodistribution and pharmacokinetic profiles were evaluated. [<sup>99m</sup>Tc]Tc-quercetin demonstrated high accumulation in colorectal tumour regions, with rapid systemic clearance and widespread tissue distribution observed in pharmacokinetic profiling. The [<sup>99m</sup>Tc]Tc-quercetin holds promise as a potential radiotracer for colorectal cancer imaging, providing important insights into its biological behaviour and diagnostic potential.</p>

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Biological studies of radiolabelled flavonoid [99mTc]Tc-quercetin as a potential candidate for colorectal cancer radiotracer

  • 期刊论文

  • 发表日期：

    2026年1月22日

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  • Rizky Juwita Sugiharti,
  • Ahmad Kurniawan,
  • Isa Mahendra,
  • Isti Daruwati,
  • Iim Halimah,
  • Maula Eka Sriyani,
  • Eva Maria Widyasari

摘要

Cancer remains a major cause of mortality, necessitating the exploration of novel therapeutic and diagnostic strategies. Quercetin is known for its antioxidant properties that may counteract carcinogenesis by neutralising free radicals. Therefore, it might be suitable to be used as a radiotracer. This study aimed to evaluate the biodistribution of technetium-99m-labelled quercetin ([99mTc]Tc-quercetin) in a carcinogen-induced colorectal cancer murine model. Quercetin was successfully radiolabelled with technetium-99m, achieving a high radiochemical yield. The radiolabelled compound was then administered to tumour-bearing mice, and its biodistribution and pharmacokinetic profiles were evaluated. [99mTc]Tc-quercetin demonstrated high accumulation in colorectal tumour regions, with rapid systemic clearance and widespread tissue distribution observed in pharmacokinetic profiling. The [99mTc]Tc-quercetin holds promise as a potential radiotracer for colorectal cancer imaging, providing important insights into its biological behaviour and diagnostic potential.