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<p>Early and accurate diagnosis of infectious processes can significantly enhance the effectiveness of therapeutic interventions. [<sup>99m</sup>Tc]Tc-HMPAO-labeled white blood cell (WBC) SPECT/CT is a well-established imaging tool for this purpose. This pictorial review illustrates the clinical utility of [<sup>99m</sup>Tc]Tc-HMPAO-WBC SPECT/CT in patients with suspected infections through case-based examples. Ten patients (5 women, 5 men; median age 57 years, range 32–84) with suspected infection based on clinical symptoms and/or elevated inflammatory markers underwent [<sup>99m</sup>Tc]Tc-HMPAO-WBC SPECT/CT between January 2023 and December 2024 at IKHC nuclear medicine center, Tehran, Iran. Of the 10 patients undergoing [<sup>99m</sup>Tc]Tc-HMPAO-WBC SPECT/CT, 4 showed radiotracer uptake indicating infection that was confirmed by clinical and/or microbiological evidence. The remaining 6 patients including 2 cases with suspected osteomyelitis (OM) and 4 cases with non-OM conditions (avascular necrosis, fever of unknown origin and fungal ear infection) revealed no radiotracer uptake and lacked sufficient clinical or laboratory evidence in support of infection.</p>

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Role of [99mTc]Tc-HMPAO-labelled white blood cell SPECT/CT in suspected infections: a pictorial review

  • 期刊论文

  • 发表日期：

    2025年12月11日

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  • Sarvenaz Mirzakhani,
  • Abolfazl Farbod,
  • Saeed Farzanehfar,
  • Mehrshad Abbasi,
  • Razieh Taatzade,
  • Niloofar Tabatabaeian,
  • Najmeh Ranjbar,
  • Mohamad Parnoon,
  • Elisabeth Eppard,
  • Nasim Vahidfar

摘要

Early and accurate diagnosis of infectious processes can significantly enhance the effectiveness of therapeutic interventions. [99mTc]Tc-HMPAO-labeled white blood cell (WBC) SPECT/CT is a well-established imaging tool for this purpose. This pictorial review illustrates the clinical utility of [99mTc]Tc-HMPAO-WBC SPECT/CT in patients with suspected infections through case-based examples. Ten patients (5 women, 5 men; median age 57 years, range 32–84) with suspected infection based on clinical symptoms and/or elevated inflammatory markers underwent [99mTc]Tc-HMPAO-WBC SPECT/CT between January 2023 and December 2024 at IKHC nuclear medicine center, Tehran, Iran. Of the 10 patients undergoing [99mTc]Tc-HMPAO-WBC SPECT/CT, 4 showed radiotracer uptake indicating infection that was confirmed by clinical and/or microbiological evidence. The remaining 6 patients including 2 cases with suspected osteomyelitis (OM) and 4 cases with non-OM conditions (avascular necrosis, fever of unknown origin and fungal ear infection) revealed no radiotracer uptake and lacked sufficient clinical or laboratory evidence in support of infection.