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<p>Gamma irradiation (30–50 kGy) was employed to enhance the mechanical properties of novel p(ATACA/AAc) hydrogels synthesized from N-(14-Amino-3,6,9,12-tetraazatetradecyl) carbamothioyl) Acrylamide monomer. The p(ATACA/AAc) (1:1) hydrogel irradiated at 50 kGy demonstrated optimal cartilage-mimetic properties with a storage modulus of 2.5&#xa0;MPa, 99% elastic recovery, and compressive strength exceeding 10&#xa0;MPa. SEM revealed a porous microstructure suitable for tissue engineering, while BMMSC assays confirmed excellent biocompatibility with robust cell attachment and chondrogenic differentiation. These gamma-irradiated hydrogels represent promising candidates for cartilage tissue engineering applications.</p>

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Radiation-Synthesized p(ATACA/AAc) hydrogel as a biomimetic scaffold for cartilage replacement in veterinary and human orthopedics

  • 期刊论文

  • 发表日期：

    2026年2月21日

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  • Reem Darwesh,
  • Sarah Alharthi,
  • Nour E. A. Abd El-Sattar,
  • Samera Ali Al-Gahtany,
  • Mohamed Madani,
  • Md Azizul Haque,
  • Ahmed A. Zaher,
  • Mohamed Mohamady Ghobashy

摘要

Gamma irradiation (30–50 kGy) was employed to enhance the mechanical properties of novel p(ATACA/AAc) hydrogels synthesized from N-(14-Amino-3,6,9,12-tetraazatetradecyl) carbamothioyl) Acrylamide monomer. The p(ATACA/AAc) (1:1) hydrogel irradiated at 50 kGy demonstrated optimal cartilage-mimetic properties with a storage modulus of 2.5 MPa, 99% elastic recovery, and compressive strength exceeding 10 MPa. SEM revealed a porous microstructure suitable for tissue engineering, while BMMSC assays confirmed excellent biocompatibility with robust cell attachment and chondrogenic differentiation. These gamma-irradiated hydrogels represent promising candidates for cartilage tissue engineering applications.