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<p>To date, radiopharmaceuticals containing micro-sized carriers of radionuclides are actively being studied, as well as their use in radioembolization instead of <sup>90</sup>Y-containing microspheres. For such purposes, bentonite clays widely studied as a carrier of drugs seems perspective but their research as carriers of radionuclides in nuclear medicine is almost absent. In this study, bentonite samples were tested for the first time as a platform for a wide range of therapeutic radionuclides. Optimal conditions for the sorption of di- and trivalent therapeutic isotopes by the studied samples were identified. Stability in model biological media was investigated. Adsorption isotherms for the corresponding elements were obtained using the Freundlich and Langmuir models, and ΔG of the adsorption processes were determined. As a result, the studied samples were found to be promising carriers of bismuth (<sup>212,213</sup>Bi) and <sup>225</sup>Ac isotopes, including an “in vivo generator” <sup>225</sup>Ac/<sup>213</sup>Bi, opening up prospects for further research in laboratory animals.</p>

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Micro-sized particles of bentonite clays as perspective carriers of therapeutic radionuclides for nuclear medicine purposes

  • 期刊论文

  • 发表日期：

    2025年10月14日

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  • Andrey G. Kazakov,
  • Evgeny Y. Khvorostinin,
  • Ekaterina A. Odintsova,
  • Taisia Y. Ekatova,
  • Sergey E. Vinokurov,
  • Vasily V. Zhigarev,
  • Daniil A. Vetugov,
  • Boris F. Myasoedov

摘要

To date, radiopharmaceuticals containing micro-sized carriers of radionuclides are actively being studied, as well as their use in radioembolization instead of 90Y-containing microspheres. For such purposes, bentonite clays widely studied as a carrier of drugs seems perspective but their research as carriers of radionuclides in nuclear medicine is almost absent. In this study, bentonite samples were tested for the first time as a platform for a wide range of therapeutic radionuclides. Optimal conditions for the sorption of di- and trivalent therapeutic isotopes by the studied samples were identified. Stability in model biological media was investigated. Adsorption isotherms for the corresponding elements were obtained using the Freundlich and Langmuir models, and ΔG of the adsorption processes were determined. As a result, the studied samples were found to be promising carriers of bismuth (212,213Bi) and 225Ac isotopes, including an “in vivo generator” 225Ac/213Bi, opening up prospects for further research in laboratory animals.