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<p>This review provides a comprehensive overview of the advancements made in radiolabeled tyrosine kinase inhibitors (TKIs) for imaging and treatment of lung cancer from the past few years. Specific topics include: the mechanism and the history of TKIs, fundamentals of PET/ SPECT imaging, and the techniques as well as the preclinical studies of radioisotope labelling TKIs. The main purpose of this review is to provide the basis for the safety and viability of using radiolabeled TKIs in clinical practice with PET/SPECT.</p> Graphical Abstract <p></p>

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Radioisotope-labeled tyrosine kinase inhibitors in the diagnosis and treatment of lung cancer

  • 期刊论文

  • 发表日期：

    2025年8月2日

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  • Muhammad Zahid,
  • Hongliang Wang,
  • Yanyan Li,
  • Jian Zhang

摘要

This review provides a comprehensive overview of the advancements made in radiolabeled tyrosine kinase inhibitors (TKIs) for imaging and treatment of lung cancer from the past few years. Specific topics include: the mechanism and the history of TKIs, fundamentals of PET/ SPECT imaging, and the techniques as well as the preclinical studies of radioisotope labelling TKIs. The main purpose of this review is to provide the basis for the safety and viability of using radiolabeled TKIs in clinical practice with PET/SPECT.

Graphical Abstract