<p>Boron is an essential micronutrient for plants found in different compartments with a high variable content from rocks and soils to waters. Boron is one of the less abundant elements in the earth’s crust. The ¹⁰B, a naturally occurring isotope of boron, has a high neutron capture cross-section. This property makes boron an effective neutron absorber, useful for various environmental, geological and agronomic applications. For example, the B detection in different matrices is key for irrigation and fertilization, waste management or prospection of new deposits, among others. In the present research a number of seven different materials are simulated to calibrate and optimize the signals for boron quantification. The three signals that are sensitive to boron content are calculated at different points for varying geometries in order to increase the sensitivity to boron content. Calibration curves are obtained for varying B contents, and some applications of these are discussed. The conclusions drawn provide a basis for the assessment of the viability of neutron and gamma detectors as calibrating tools within simulated setups.</p>