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<p>This study investigates the synthesis, characterization, and in vivo evaluation of Samarium-153 microspheres. Samarium microspheres were synthesized via a hydrothermal method and characterized for morphology, shape, and size. Neutron irradiation and radioactive characterization confirmed nearly 100% radionuclide purity. The MS-02 sample showed optimal morphology with a size of 951.3 ± 223.3&#xa0;nm, as confirmed by TEM, SEM-EDS, PSA, and XRD. Stability tests indicated no degradation in 0.9% saline, 0.1&#xa0;M PB pH 7.4, and 3% BSA. In vivo studies in normal BALB/c mice showed significant distribution in the liver, lungs, and spleen, providing valuable biodistribution data for further development.</p> Graphical abstract <p></p>

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Preliminary study of a transarterial radioembolization agent using Samarium-153 microspheres: synthesis, characterization, and in vivo evaluation in normal mice

  • 期刊论文

  • 发表日期：

    2025年5月22日

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  • Amal Rezka Putra,
  • Andi Arjuna,
  • Herlan Setiawan,
  • Aulia Arivin Billah,
  • Sumandi Juliyanto,
  • Ahsanal Fikri,
  • Indra Saptiama,
  • Miftakul Munir,
  • Marissa Angelina,
  • Rizal Maarif Rukmana,
  • Isa Mahendra,
  • Veronika Yulianti Susilo,
  • Ligwina Dita Pertiwi,
  • Wening Lestari,
  • Boky Jeanne Tuasikal,
  • Rien Ritawidya

摘要

This study investigates the synthesis, characterization, and in vivo evaluation of Samarium-153 microspheres. Samarium microspheres were synthesized via a hydrothermal method and characterized for morphology, shape, and size. Neutron irradiation and radioactive characterization confirmed nearly 100% radionuclide purity. The MS-02 sample showed optimal morphology with a size of 951.3 ± 223.3 nm, as confirmed by TEM, SEM-EDS, PSA, and XRD. Stability tests indicated no degradation in 0.9% saline, 0.1 M PB pH 7.4, and 3% BSA. In vivo studies in normal BALB/c mice showed significant distribution in the liver, lungs, and spleen, providing valuable biodistribution data for further development.

Graphical abstract