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<p>The crosslinked biopolymers along with metal oxide nanoparticles are biodegradable source of controlled drug release. In this research work, the natural and synthetic biopolymers, oxidized starch (OS) and polyvinyl alcohol (PVA) were crosslinked by using borate ions to prepare hydrogel 3D matrix. The zinc oxide nanoparticles (ZnO-NPs) were integrated by immersion method by using different concentrations (0, 1%, 2%, 3% and 4% (w/v)) of zinc chloride solution for 24&#xa0;h and the zinc ions loaded hydrogel was immersed in 5% (w/v) solution of sodium hydroxide for 24&#xa0;h to integrate ZnO-NPs in OS/PVA hydrogel matrix. The corn starch was oxidized by using the hydrogen peroxide and copper sulphate to get oxidized starch. The silver nanoparticles were used as an active SERS substrate. The vancomycin was loaded by in-situ method on OS/PVA/ZnO hydrogel to analyze its controlled release at 7.4 pH in phosphate buffer solution at 37&#xa0;°C. Its swelling behavior in different solutions, antibacterial activities, cytotoxicity against human colon cancer cells (SW480) and hemolytic analysis were evaluated. The Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, scanning electron microscope (SEM), UV-Vis spectrophotometer and X-ray diffraction (XRD) characterizations techniques were used for the surface morphology, structural investigation, and identification of nanoparticles in the polymer matrix. Drug release concentrations were analyzed by UV-Vis spectrophotometer and Surface-enhanced Raman spectroscopy (SERS) coupled with Partial Least Squares Regression (PLSR) with 0.752 ppm LOD and 3.24 ppm LOQ for highest ZnO concentration (C4) hydrogel. The drug release kinetics were determined using four kinetic models that included Zero-order, First-order, Higuchi and Korsmeyer-Peppas. The prepared nanobiocomposite hydrogels showed remarkable enhanced biological potential and controlled drug release behavior as an active antibacterial drug delivery agent.</p>

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Preparation of oxidized Starch/PVA/ZnO Nanobiocomposite hydrogel as drug delivery agent: SERS-Driven vancomycin In-vitro release kinetics and biological potential evaluation

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Awaji Y. Safhi,
  • Amar Yasser Jassim,
  • Khalaf F. Alsharif,
  • Fuad M. Alzahrani,
  • Khalid J. Alzahrani,
  • Arslan Bashir,
  • Anfal Fatima,
  • Nasir Mehmood

摘要

The crosslinked biopolymers along with metal oxide nanoparticles are biodegradable source of controlled drug release. In this research work, the natural and synthetic biopolymers, oxidized starch (OS) and polyvinyl alcohol (PVA) were crosslinked by using borate ions to prepare hydrogel 3D matrix. The zinc oxide nanoparticles (ZnO-NPs) were integrated by immersion method by using different concentrations (0, 1%, 2%, 3% and 4% (w/v)) of zinc chloride solution for 24 h and the zinc ions loaded hydrogel was immersed in 5% (w/v) solution of sodium hydroxide for 24 h to integrate ZnO-NPs in OS/PVA hydrogel matrix. The corn starch was oxidized by using the hydrogen peroxide and copper sulphate to get oxidized starch. The silver nanoparticles were used as an active SERS substrate. The vancomycin was loaded by in-situ method on OS/PVA/ZnO hydrogel to analyze its controlled release at 7.4 pH in phosphate buffer solution at 37 °C. Its swelling behavior in different solutions, antibacterial activities, cytotoxicity against human colon cancer cells (SW480) and hemolytic analysis were evaluated. The Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, scanning electron microscope (SEM), UV-Vis spectrophotometer and X-ray diffraction (XRD) characterizations techniques were used for the surface morphology, structural investigation, and identification of nanoparticles in the polymer matrix. Drug release concentrations were analyzed by UV-Vis spectrophotometer and Surface-enhanced Raman spectroscopy (SERS) coupled with Partial Least Squares Regression (PLSR) with 0.752 ppm LOD and 3.24 ppm LOQ for highest ZnO concentration (C4) hydrogel. The drug release kinetics were determined using four kinetic models that included Zero-order, First-order, Higuchi and Korsmeyer-Peppas. The prepared nanobiocomposite hydrogels showed remarkable enhanced biological potential and controlled drug release behavior as an active antibacterial drug delivery agent.