Scholarlink

<p>In this study, a nanocomposite hydrogel containing dextran (Dex), 4-acryloylmorpholine (AcM), 2-amido-2-methyl-1-propanesulphonic acid (AMPS), and silver nanoparticles (SNPs) was made by a microwave-assisted free radical polymerization method. The material was characterized by advanced analytical techniques and evaluated as a vehicle for the oral co-delivery of 5-fluorouracil (5-FU) and cisplatin (CPT) in cancer treatment. The drugs were encapsulated in the matrix from an aqueous solution. Subsequently, a release study was performed in pH 1.2 medium, as simulated gastric fluid and in pH 7.4 medium, as simulated intestinal fluid. The drug encapsulation efficiencies were 84.1 % for 5-FU and 72.7 % for CPT. The maximum cumulative drug release was observed at pH 7.4, reaching 93.6 % for 5-FU and 82.9 % for CPT within 24&#xa0;h. The first-order kinetic and Higuchi square-root models best described the drug-release process, which followed a non-Fickian diffusion mechanism. A cytotoxicity study showed good cytocompatibility of the drug-loaded nanocomposite towards MCF-10&#xa0;A normal cells and severe toxicity towards MCF-7 cancer cells. The results suggest that the prepared nanocomposite is a promising polymer matrix material for the co-delivery of 5-FU and CPT via the gastrointestinal tract for cancer management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preparation of graft-copolymer nanocomposite containing dextran as a pH-responsive functional polymer matrix material for oral co-delivery of 5-fluorouracil and cisplatin

  • 期刊论文

  • 发表日期：

    2026年4月25日

查看全文
  • Amos Luanda,
  • Manohar Mahadev,
  • Rompicherla Narayana Charyulu,
  • Vishalakshi Badalamoole

摘要

In this study, a nanocomposite hydrogel containing dextran (Dex), 4-acryloylmorpholine (AcM), 2-amido-2-methyl-1-propanesulphonic acid (AMPS), and silver nanoparticles (SNPs) was made by a microwave-assisted free radical polymerization method. The material was characterized by advanced analytical techniques and evaluated as a vehicle for the oral co-delivery of 5-fluorouracil (5-FU) and cisplatin (CPT) in cancer treatment. The drugs were encapsulated in the matrix from an aqueous solution. Subsequently, a release study was performed in pH 1.2 medium, as simulated gastric fluid and in pH 7.4 medium, as simulated intestinal fluid. The drug encapsulation efficiencies were 84.1 % for 5-FU and 72.7 % for CPT. The maximum cumulative drug release was observed at pH 7.4, reaching 93.6 % for 5-FU and 82.9 % for CPT within 24 h. The first-order kinetic and Higuchi square-root models best described the drug-release process, which followed a non-Fickian diffusion mechanism. A cytotoxicity study showed good cytocompatibility of the drug-loaded nanocomposite towards MCF-10 A normal cells and severe toxicity towards MCF-7 cancer cells. The results suggest that the prepared nanocomposite is a promising polymer matrix material for the co-delivery of 5-FU and CPT via the gastrointestinal tract for cancer management.