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<p>This study investigated the fabrication of sodium alginate (SA) microparticles embedded in polyvinyl alcohol (PVA) hydrogel for tissue regeneration applications. The combination of SA and PVA produces composite hydrogels with enhanced mechanical performance and tunable degradation behavior. SA microparticles were incorporated into a PVA matrix using a freeze–thaw technique to form composite hydrogel scaffolds. The physicochemical and mechanical properties of the scaffolds were systematically evaluated to determine their suitability for wound healing applications. The results of this study provide significant information about the potential of SA microparticles embedded in PVA hydrogel for wound healing. Incorporation of SA microparticles enhanced the physicochemical and mechanical properties of the hydrogel, while reducing the water vapor transmission rate (WVTR) without significantly affecting moisture content compared to pure PVA hydrogel. These findings indicate that the SA/PVA composite hydrogel exhibits favorable physicochemical and mechanical characteristics for potential use as a wound dressing material.</p>

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Fabrication of sodium alginate microparticles embedded in PVA hydrogel as potential wound dressing materials

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Iqra Mohammad Hanif,
  • Savaira Noman Hashmi,
  • Amna Feroze Hadiawala,
  • Tooba Khan,
  • Abdul Moiz

摘要

This study investigated the fabrication of sodium alginate (SA) microparticles embedded in polyvinyl alcohol (PVA) hydrogel for tissue regeneration applications. The combination of SA and PVA produces composite hydrogels with enhanced mechanical performance and tunable degradation behavior. SA microparticles were incorporated into a PVA matrix using a freeze–thaw technique to form composite hydrogel scaffolds. The physicochemical and mechanical properties of the scaffolds were systematically evaluated to determine their suitability for wound healing applications. The results of this study provide significant information about the potential of SA microparticles embedded in PVA hydrogel for wound healing. Incorporation of SA microparticles enhanced the physicochemical and mechanical properties of the hydrogel, while reducing the water vapor transmission rate (WVTR) without significantly affecting moisture content compared to pure PVA hydrogel. These findings indicate that the SA/PVA composite hydrogel exhibits favorable physicochemical and mechanical characteristics for potential use as a wound dressing material.