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<p>Porous films based on curcumin-loaded chitosan-grafted graphene oxide (CCGO) were developed as potential wound healing materials. The chemical constitution and microstructure of the films were characterized using FTIR, XRD, SEM and EDX analysis. Among the developed films, the CCGO film containing 0.6 wt% curcumin exhibited a pore diameter of 485&#xa0;μm, a porosity of 79.45 ± 2.92%, a swelling capacity of 306 ± 5.6%, a water retention ability of 360 ± 6.67%, and a controlled biodegradability of 88 ± 2.66%. Due to the presence of curcumin, the CCGO films exhibited antimicrobial activity, showing inhibition zones ranging from 14 to 22&#xa0;mm against Gram-positive and Gram-negative bacteria, and 0–22&#xa0;mm against fungi, when compared to the control chitosan-grafted graphene oxide (CGO) film. Cytotoxicity studies confirmed that the CCGO films were non-toxic to the C3H10T1/2 cell line, regardless of their curcumin content. Furthermore, in vitro scratch assays revealed that the CCGO film containing 0.6 wt% curcumin promoted complete (100%) cell migration, proliferation, and wound closure within 12&#xa0;h, compared to the CGO film. These findings suggest that CCGO films could serve as potential materials for wound healing applications. This work differs from previous studies on curcumin, chitosan, or graphene oxide (GO) by developing CCGO films that exhibit synergistic enhancements in structure, antimicrobial activity, and wound healing potential.</p>

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Curcumin-loaded chitosan-graft-graphene oxide films as wound healing materials

  • 期刊论文

  • 发表日期：

    2026年2月23日

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  • Sathya Seeli David,
  • Prasanna Pugazhendhi,
  • Kiran Joy,
  • Prabaharan Mani

摘要

Porous films based on curcumin-loaded chitosan-grafted graphene oxide (CCGO) were developed as potential wound healing materials. The chemical constitution and microstructure of the films were characterized using FTIR, XRD, SEM and EDX analysis. Among the developed films, the CCGO film containing 0.6 wt% curcumin exhibited a pore diameter of 485 μm, a porosity of 79.45 ± 2.92%, a swelling capacity of 306 ± 5.6%, a water retention ability of 360 ± 6.67%, and a controlled biodegradability of 88 ± 2.66%. Due to the presence of curcumin, the CCGO films exhibited antimicrobial activity, showing inhibition zones ranging from 14 to 22 mm against Gram-positive and Gram-negative bacteria, and 0–22 mm against fungi, when compared to the control chitosan-grafted graphene oxide (CGO) film. Cytotoxicity studies confirmed that the CCGO films were non-toxic to the C3H10T1/2 cell line, regardless of their curcumin content. Furthermore, in vitro scratch assays revealed that the CCGO film containing 0.6 wt% curcumin promoted complete (100%) cell migration, proliferation, and wound closure within 12 h, compared to the CGO film. These findings suggest that CCGO films could serve as potential materials for wound healing applications. This work differs from previous studies on curcumin, chitosan, or graphene oxide (GO) by developing CCGO films that exhibit synergistic enhancements in structure, antimicrobial activity, and wound healing potential.