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<p>Hybrid stimuli-responsive hydrogels have attracted considerable attention in various biomedical fields, including intelligent drug delivery, disease treatment, and wound dressing. In this study, the behaviour of hybrid poly(N-isopropylacrylamide) (pNIPAAm) hydrogels physically cross-linked by acid-activated synthetic hectorite Laponite® (Lap) platelets was investigated. Nitrogen adsorption measurements, analyzed using the BET and t-plot methods, were employed to estimate the contributions of small nanopores, micropores, and external pores to the specific surface area. The swelling behaviour and DSC thermograms of pNIPAAm hydrogels containing Lap or acid-activated Lap (LapA) platelets were analyzed. The degree of swelling decreased with increasing temperature and showed a pronounced reduction near the lower critical solution temperature (LCST), located at approximately 33–34&#xa0;°C for all samples. The effects of platelet incorporation on the swelling behaviour are discussed in detail. DSC measurements were performed over the temperature range corresponding to the gel–sol transition (28–45&#xa0;°C) during both heating and cooling cycles. The enthalpy of the phase transition varied considerably among the samples, reflecting differences in the interactions between the pNIPAAm networks and the Lap/LapA platelets.</p> Graphical Abstract <p></p>

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Hybrid pNIPAAm hydrogels cross-linked by acid-activated Laponite®: Impact of nanoplatelets on swelling and thermodynamic properties

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Olena Samoylenko,
  • Yurii Samchenko,
  • Olena Solovieva,
  • Liudmyla Kernosenko,
  • Tetiana Poltoratskaya,
  • Natalia Pasmurtseva,
  • Irina Ganusevich,
  • Olga Vashchenko,
  • Longin Lisetski,
  • Nikolai Lebovka

摘要

Hybrid stimuli-responsive hydrogels have attracted considerable attention in various biomedical fields, including intelligent drug delivery, disease treatment, and wound dressing. In this study, the behaviour of hybrid poly(N-isopropylacrylamide) (pNIPAAm) hydrogels physically cross-linked by acid-activated synthetic hectorite Laponite® (Lap) platelets was investigated. Nitrogen adsorption measurements, analyzed using the BET and t-plot methods, were employed to estimate the contributions of small nanopores, micropores, and external pores to the specific surface area. The swelling behaviour and DSC thermograms of pNIPAAm hydrogels containing Lap or acid-activated Lap (LapA) platelets were analyzed. The degree of swelling decreased with increasing temperature and showed a pronounced reduction near the lower critical solution temperature (LCST), located at approximately 33–34 °C for all samples. The effects of platelet incorporation on the swelling behaviour are discussed in detail. DSC measurements were performed over the temperature range corresponding to the gel–sol transition (28–45 °C) during both heating and cooling cycles. The enthalpy of the phase transition varied considerably among the samples, reflecting differences in the interactions between the pNIPAAm networks and the Lap/LapA platelets.

Graphical Abstract