Scholarlink

<p>The demand for sustainable drug delivery systems has driven research into biodegradable polymers with improved performance characteristics. Polylactic acid (PLA), a biocompatible and FDA-approved polymer, holds promise in biomedical applications but is limited by slow degradation rates and insufficient antimicrobial activity. This study develops electrospun PLA nanofibers infused with Tulsi (Ocimum sanctum) essential oil to improve sustained drug release, antimicrobial activity, and biodegradability. Physicochemical properties analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and contact angle measurements revealed smooth morphology and increased hydrophobicity (88.4°). Drug release kinetics modeled using Korsmeyer-Peppas equations indicated a diffusion-controlled mechanism with R² value of 0.8022, enabling sustained release over 30 days. The nanofibers exhibited antibacterial efficacy against Escherichia coli and Staphylococcus aureus with inhibition zones of 1.2&#xa0;cm and antifungal activity against Aspergillus niger with zones up to 1.0&#xa0;cm. Degradation studies revealed accelerated biodegradation, with 81.4% weight loss in 30 days under simulated environmental conditions. These results showcase the multifunctional performance of Tulsi-infused PLA nanofibers, offering sustained drug release, antimicrobial activity, and eco-friendly degradation. This study highlights their potential for biomedical applications, such as wound dressings and antimicrobial coatings, while paving the way for advanced polymer systems and dual-drug delivery strategies.</p> Graphical Abstract <p>The graphical abstract depicts the synthesis of electrospun polylactic acid (PLA) nanofibers functionalized with Tulsi essential oil. Starting from PLA pellets, the electrospinning process yields nanofibers with enhanced antimicrobial activity and sustained drug release properties. Fourier-transform infrared (FTIR) spectroscopy confirms the successful encapsulation of Germacrene D. These nanofibers demonstrate potential applications in wound dressings, antimicrobial coatings, and environmentally sustainable biomedical systems.</p> <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Tailoring electrospun polylactic acid nanofibers for sustained drug release and controlled delivery applications

  • 期刊论文

  • 发表日期：

    2025年8月15日

查看全文
  • Anshuman Gupta,
  • Vishwanath Gholap,
  • Balasubramanian Kandasubramanian

摘要

The demand for sustainable drug delivery systems has driven research into biodegradable polymers with improved performance characteristics. Polylactic acid (PLA), a biocompatible and FDA-approved polymer, holds promise in biomedical applications but is limited by slow degradation rates and insufficient antimicrobial activity. This study develops electrospun PLA nanofibers infused with Tulsi (Ocimum sanctum) essential oil to improve sustained drug release, antimicrobial activity, and biodegradability. Physicochemical properties analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and contact angle measurements revealed smooth morphology and increased hydrophobicity (88.4°). Drug release kinetics modeled using Korsmeyer-Peppas equations indicated a diffusion-controlled mechanism with R² value of 0.8022, enabling sustained release over 30 days. The nanofibers exhibited antibacterial efficacy against Escherichia coli and Staphylococcus aureus with inhibition zones of 1.2 cm and antifungal activity against Aspergillus niger with zones up to 1.0 cm. Degradation studies revealed accelerated biodegradation, with 81.4% weight loss in 30 days under simulated environmental conditions. These results showcase the multifunctional performance of Tulsi-infused PLA nanofibers, offering sustained drug release, antimicrobial activity, and eco-friendly degradation. This study highlights their potential for biomedical applications, such as wound dressings and antimicrobial coatings, while paving the way for advanced polymer systems and dual-drug delivery strategies.

Graphical Abstract

The graphical abstract depicts the synthesis of electrospun polylactic acid (PLA) nanofibers functionalized with Tulsi essential oil. Starting from PLA pellets, the electrospinning process yields nanofibers with enhanced antimicrobial activity and sustained drug release properties. Fourier-transform infrared (FTIR) spectroscopy confirms the successful encapsulation of Germacrene D. These nanofibers demonstrate potential applications in wound dressings, antimicrobial coatings, and environmentally sustainable biomedical systems.