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<p>Magnetic hyperthermia therapy represents a cutting-edge oncological treatment that harnesses the localized heating of magnetic nanoparticles (MNPs) under an alternating magnetic field (AMF). In this study, monodisperse nickel ferrite (NiFe<sub>2</sub>O<sub>4</sub>) nanoparticles were synthesized via a controlled thermal decomposition strategy to achieve optimized magnetic characteristics suitable for biomedical hyperthermia. The synthesis conditions were systematically tuned using 7.5&#xa0;mmol of oleylamine and oleic acid as surfactants, yielding highly uniform nanoparticles with enhanced superparamagnetic properties. Structural and morphological characterization using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) confirmed the formation of a pure spinel phase with narrow size distribution, while magnetic measurements via vibrating sample magnetometry (VSM) revealed a high saturation magnetization of 29.1&#xa0;emu/g and low coercivity of 58.3 Oe. Notably, the obtained SLP value of 85.3 W/g under 400 Oe and 400&#xa0;kHz confirms the heating capability of the nanoparticles for magnetic hyperthermia applications. These findings establish thermally tailored NiFe<sub>2</sub>O<sub>4</sub> nanoparticles as promising candidates for advanced magnetically driven therapeutic platforms.</p>

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Thermally Engineered NiFe2O4 Nanoparticles via Controlled Decomposition: A High-Performance Candidate for Magnetic Hyperthermia Applications-Based Cancer Therapy

  • 期刊论文

  • 发表日期：

    2025年9月19日

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  • Moatasem Oudah AL-Sawafi,
  • Nadir M. Nanakali,
  • Ali Abbasi,
  • Mohammad Waleed M. Sadaka,
  • Sattar H. Abed,
  • Shaymaa Awad kadhim,
  • Masoomeh Sadat Fini,
  • Kamran Heydaryan

摘要

Magnetic hyperthermia therapy represents a cutting-edge oncological treatment that harnesses the localized heating of magnetic nanoparticles (MNPs) under an alternating magnetic field (AMF). In this study, monodisperse nickel ferrite (NiFe2O4) nanoparticles were synthesized via a controlled thermal decomposition strategy to achieve optimized magnetic characteristics suitable for biomedical hyperthermia. The synthesis conditions were systematically tuned using 7.5 mmol of oleylamine and oleic acid as surfactants, yielding highly uniform nanoparticles with enhanced superparamagnetic properties. Structural and morphological characterization using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) confirmed the formation of a pure spinel phase with narrow size distribution, while magnetic measurements via vibrating sample magnetometry (VSM) revealed a high saturation magnetization of 29.1 emu/g and low coercivity of 58.3 Oe. Notably, the obtained SLP value of 85.3 W/g under 400 Oe and 400 kHz confirms the heating capability of the nanoparticles for magnetic hyperthermia applications. These findings establish thermally tailored NiFe2O4 nanoparticles as promising candidates for advanced magnetically driven therapeutic platforms.