<p>The Asclepieia of ancient Greece functioned as healing sanctuaries in which religious ritual and therapeutic practice were closely intertwined. They did not constitute a clear separation between religion and medicine, as they embodied one of the most structured forms of ritualized healing in the classical world, in which ritual and empirical medicine operated side by side. Drawing on archaeological, epigraphic, historical, and medical–historical evidence, this narrative review examines the therapeutic, organizational, and symbolic dimensions of the Asclepieia as early models of holistic health care. Emphasis is placed on the rituals of incubation, environmental design, psychological expectations, and practical therapeutic interventions in important healing sanctuaries, such as those of Epidaurus and Kos. The findings suggest that the Asclepieia functioned not only as sacred religious centers but also as organized healing environments that combined spiritual faith, patient experience, and empirical medical practice. From a modern perspective, the Asclepieia model can be interpreted as a historical antecedent that shares certain features with contemporary biopsychosocial and patient-centered approaches to health care, emphasizing the therapeutic importance of faith, the environment, and organized care in the healing process.</p>