<p>The study aimed to determine the relationship between religious coping and the quality of life of hemodialysis patients&#xa0;in Somalia. This cross-sectional and correlational study was conducted with 174 -12 Health Survey hemodialysis patients in April–July 2024 in the hemodialysis unit of a Training and Research Hospital in Somalia. The data were collected using the Patient Identification Form, Religious Coping Scale, and Short Form (SF-12). A significant positive correlation was found between patients’ positive religious coping scores (<i>r</i> = 0.270; <i>p</i> &lt; 0.05), physical (<i>r</i> = 0.177; <i>p</i> &lt; 0.05), and mental quality of life and age (<i>r</i> = 0.363; <i>p</i> &lt; 0.05). Additionally, there was a negative correlation between physical quality of life and hemodialysis duration (<i>r</i> =  − 0.170; <i>p</i> &lt; 0.05) and a negative correlation between mental quality of life and age (<i>r</i> =  − 0.231; <i>p</i> &lt; 0.05). In the multiple linear regression analysis, 15.2% of the total variance in physical quality of life was explained by occupation, positive religious coping, and duration of hemodialysis (<i>F</i> = 10.171. <i>p</i> = 0.000. <i>R</i>² = 0.152; <i>R</i> = 0.390). The total variance at the mental quality of life level was explained by living with whom and vascular access with a rate of 13.8% (<i>F</i> = 5.363. <i>p</i> = 0.000. <i>R</i>² = 0.138; <i>R</i> = 0.372). Positive religious coping was associated with improved mental and physical health-related quality of life in hemodialysis patients.</p>