<p>This historical review aims not only to identify and analyse artistic depictions of miraculous healings of various injuries and orthopaedic pathologies affecting the foot and leg over the centuries, but also to explore the stories of the saints portrayed and the exceptional artists who brought these miracles to life through their masterpieces. By examining historical and artistic sources, this study traces the evolution of healing iconography from the earliest descriptions in the sixth century, through the Middle Ages to the Renaissance. Special attention is given to the increasing anatomical accuracy in these works of art, influenced by Renaissance figures such as Andreas Vesalius, who collaborated with artists like Titian. An iconographic analysis reveals the symbolic and didactic roles of these artworks in both religious and medical contexts. Findings reveal that religious art functioned both as a vehicle for theological messages and as an educational medical tool, strengthening the belief in divine healing and promoting new perspectives in the advances of active and dynamic medical science. These depictions supported the rise of church-affiliated hospitals, marking a transition from purely miraculous healing to practices grounded in anatomy and empirical medicine. This study highlights how depictions of foot and leg healing in religious art functioned simultaneously as expressions of faith and as vehicles for medical education for embracing new medical insights. This dynamic interplay between art, religion and medicine laid the foundation for the integration of visual representation into modern medical science, ultimately shaping the evolution of orthopaedics and anatomical understanding in subsequent centuries.</p>