<p>This study explores spiritual well-being among parents of children with hearing impairment and how self-regulation and resilience relate to spiritual well-being in mainland China. The Self-Regulation Scale, the Resilience Scale, and the 4-Item Spiritual Well-Being Index were administered to 416 parents of children with hearing impairment. Results indicated that self-regulation positively affected resilience, and resilience positively affected spiritual well-being. Notably, resilience, as a mediating variable, weakened the effect of self-regulation on spiritual well-being. The contributions, limitations, and implications of the present research are discussed.</p>