<p>Alexithymic features are known contributors to the development and maintenance of obsessive-compulsive disorder (OCD) and its associated suicidal risk. However, the underlying mechanisms connecting these factors remain unclear. This study, involving 302 individuals with OCD, aimed to elucidate these potential mechanisms by evaluating the interplay among alexithymia subscales (e.g., difficulty in identifying feelings (DIF), difficulty in describing feelings (DDF), and externally oriented thinking (EOT)), self-regulatory strategies (emotional suppression, cognitive reappraisal, and experiential avoidance), depressive symptoms, OCD unacceptable thoughts, and suicidal risk. Initially, DIF showed substantial indirect effects on both unacceptable thoughts and suicidal risk, mediated by experiential avoidance. Furthermore, DIF indirectly influenced suicidal risk through a serial mediation involving experiential avoidance and unacceptable thoughts. However, after controlling for depression, the only significant pathway observed was DIF’s indirect effect on unacceptable thoughts, mediated by experiential avoidance. When depression was subsequently incorporated as a mediator, DIF exhibited a significant indirect effect on unacceptable obsessional thoughts via experiential avoidance. Notably, both DIF and DDF demonstrated significant indirect effects on unacceptable thoughts and suicidal risk, with depression serving as a mediator. Finally, the indirect associations of DIF with both suicidal risk and unacceptable obsessional thoughts were significant when experiential avoidance and depression functioned as serial mediators. Overall, this research highlights the role of experiential avoidance in the DDF-unacceptable thoughts link, even beyond depression, while underscoring depression’s crucial role in how experiential avoidance and unacceptable thoughts contribute to the connection between specific alexithymic features and suicidal risk.</p>