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<p>Hollow silica nanoparticles have attracted significant attention for biomedical applications owing to their high surface area and excellent chemical stability. However, their practical utilization has been limited by the lack of intrinsic signal transduction capability, which hinders real-time monitoring and tracking in biological systems. In this study, we report the synthesis of carbon quantum dot–incorporated hollow silica nanomaterials using carbon nanospheres as hard templates, followed by in situ generation of carbon quantum dots (CQDs) within the silica matrix. Transmission electron microscopy revealed that the resulting hollow silica possessed a uniform spherical morphology with an average diameter of 165.9&#xa0;nm and a silica shell thickness of approximately 45&#xa0;nm. X-ray diffraction confirmed the amorphous nature of the silica framework with a characteristic broad peak at 2θ ≈ 22°. Nitrogen adsorption–desorption analysis indicated a high specific surface area of 520.76&#xa0;m².g⁻¹, a pore volume of 0.505&#xa0;cm³.g⁻¹, and a pore diameter of 1.5&#xa0;nm. Using ibuprofen as a model drug, the CQDs-incorporated nanosilica exhibited a drug-loading efficiency of 34.72%. Photoluminescence and diffuse reflectance spectroscopy demonstrated strong green emission under suitable excitation with an estimated optical band gap of 4.41&#xa0;eV. Furthermore, cytotoxicity evaluation using L929 cells showed a high survival rate of 98.5% at a concentration of 62.5&#xa0;µg.mL⁻¹, confirming the excellent biocompatibility of the material. This study highlights the development of an integrated nanostructure in which carbon quantum dots are synthesized in situ within the hollow silica framework, enabling a fluorescent and biocompatible nanocarrier platform with strong potential for future drug delivery applications.</p>

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Hollow nanosilica incorporated with carbon quantum dots as green-emitting nanocarriers

  • 期刊论文

  • 发表日期：

    2025年12月27日

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  • Van Quy Nguyen,
  • Tran Vu Ha,
  • Do Thi Huong,
  • Tran Thao Trang,
  • Ly Tan Nhiem

摘要

Hollow silica nanoparticles have attracted significant attention for biomedical applications owing to their high surface area and excellent chemical stability. However, their practical utilization has been limited by the lack of intrinsic signal transduction capability, which hinders real-time monitoring and tracking in biological systems. In this study, we report the synthesis of carbon quantum dot–incorporated hollow silica nanomaterials using carbon nanospheres as hard templates, followed by in situ generation of carbon quantum dots (CQDs) within the silica matrix. Transmission electron microscopy revealed that the resulting hollow silica possessed a uniform spherical morphology with an average diameter of 165.9 nm and a silica shell thickness of approximately 45 nm. X-ray diffraction confirmed the amorphous nature of the silica framework with a characteristic broad peak at 2θ ≈ 22°. Nitrogen adsorption–desorption analysis indicated a high specific surface area of 520.76 m².g⁻¹, a pore volume of 0.505 cm³.g⁻¹, and a pore diameter of 1.5 nm. Using ibuprofen as a model drug, the CQDs-incorporated nanosilica exhibited a drug-loading efficiency of 34.72%. Photoluminescence and diffuse reflectance spectroscopy demonstrated strong green emission under suitable excitation with an estimated optical band gap of 4.41 eV. Furthermore, cytotoxicity evaluation using L929 cells showed a high survival rate of 98.5% at a concentration of 62.5 µg.mL⁻¹, confirming the excellent biocompatibility of the material. This study highlights the development of an integrated nanostructure in which carbon quantum dots are synthesized in situ within the hollow silica framework, enabling a fluorescent and biocompatible nanocarrier platform with strong potential for future drug delivery applications.