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<p>In this study, we developed a novel drug delivery system, PAA-2@pSiNPs@1, designed to enhance drug loading capacity and control drug release, particularly for the treatment of AMI. The composite material was synthesized by incorporating PAA-2 into pSiNPs, with compound 1 successfully encapsulated within the structure. The PAA-2 coating significantly influenced the drug release kinetics, improving the stability of the drug-loaded nanoparticles. Furthermore, the PAA-2@pSiNPs@1 system demonstrated excellent selective detection of Troponin in complex environments, making it especially suitable for AMI diagnosis and monitoring. Additionally, drug release studies were conducted in phosphate-buffered saline (PBS) at different pH values (pH 7.4, 6.5, and 4) to simulate physiological conditions. The results revealed pH-dependent release characteristics. At physiological pH (7.4), drug release was slow, whereas at lower pH values, the release rate was faster, showcasing the system’s potential for controlled drug release. The composite material exhibited high drug loading efficiencies for both hydrophilic and hydrophobic drugs, such as DOX, paclitaxel (PTX), and SN-38, further confirming its broad applicability in various drug delivery systems. Finally, using an ischemia/reperfusion (I/R) injury model in H9c2 cells, we evaluated the inhibitory effect of PAA-2@pSiNPs@1 on oxidative stress-induced myocardial cell damage.</p>

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Porous silica nanoparticles as natural drug delivery system inhibit myocardial ischemia-reperfusion injury by alleviating oxidative stress

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Jun Pu,
  • Rongchuan Yue,
  • Yanman Li,
  • Ofe Eugene Kwaku

摘要

In this study, we developed a novel drug delivery system, PAA-2@pSiNPs@1, designed to enhance drug loading capacity and control drug release, particularly for the treatment of AMI. The composite material was synthesized by incorporating PAA-2 into pSiNPs, with compound 1 successfully encapsulated within the structure. The PAA-2 coating significantly influenced the drug release kinetics, improving the stability of the drug-loaded nanoparticles. Furthermore, the PAA-2@pSiNPs@1 system demonstrated excellent selective detection of Troponin in complex environments, making it especially suitable for AMI diagnosis and monitoring. Additionally, drug release studies were conducted in phosphate-buffered saline (PBS) at different pH values (pH 7.4, 6.5, and 4) to simulate physiological conditions. The results revealed pH-dependent release characteristics. At physiological pH (7.4), drug release was slow, whereas at lower pH values, the release rate was faster, showcasing the system’s potential for controlled drug release. The composite material exhibited high drug loading efficiencies for both hydrophilic and hydrophobic drugs, such as DOX, paclitaxel (PTX), and SN-38, further confirming its broad applicability in various drug delivery systems. Finally, using an ischemia/reperfusion (I/R) injury model in H9c2 cells, we evaluated the inhibitory effect of PAA-2@pSiNPs@1 on oxidative stress-induced myocardial cell damage.