Scholarlink

<p>To evaluate diffusion model-based artificial intelligence approaches for generating virtual populations with physiological determinants of drug dosing (PDODD) and pharmacokinetic (PK) profiles.&#xa0;A denoising diffusion probabilistic model (DDPM) was applied to a 31-variable dataset of PDODD covariates (18 continuous, 13 binary) from the National Health and Nutrition Examination Survey and compared to a tabular variational autoencoder (TVAE). For nivolumab PK data (12,000 patients, 13 time points, 5 covariates), sequence-based diffusion model (SDM) and a time-aware diffusion model (TDM) with temporal self-attention were evaluated. The predictive performance of the TDM was evaluated by imputing masked time points. All models were trained and tested on 80%:20% partitions of the data using univariate, bivariate, and multivariate distributional similarity metrics.&#xa0;The diffusion model satisfactorily approximated the univariate distributions of continuous PDODD biomarkers (mean Kolmogorov-Smirnov D-statistic, KSD = 0.014), disease status frequencies (mean absolute error, MAE = 0.31%), and preserved bivariate correlations (MAE = 0.033). DDPM outperformed TVAE for categorical variables (0.31% vs. 1.07% MAE) and correlation (0.033 vs. 0.091 MAE). For nivolumab PK, SDM has KSD of 0.047 and a relative error of 1.36%. TDM accurately imputed missing PK timepoints (KSD = 0.014), reconstructing masked Day 1, Peak concentration (Cmax) Dose-9, and Terminal phase concentrations with MAE of 0.43%, 0.25%, and 0.76%, and correlations ≥ 0.999.&#xa0;Diffusion models demonstrated strong performance in generating cross-sectional PK covariate data and longitudinal PK profiles, capturing complex distributional and temporal dependencies. Diffusion-based approaches provide a flexible and robust framework for virtual simulations in pharmacometrics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Diffusion models for virtual populations and pharmacometric simulations

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月29日

查看全文
  • Prathamesh Kishor Gadgil,
  • Shamith Manjunath Poojari,
  • Murali Ramanathan

摘要

To evaluate diffusion model-based artificial intelligence approaches for generating virtual populations with physiological determinants of drug dosing (PDODD) and pharmacokinetic (PK) profiles. A denoising diffusion probabilistic model (DDPM) was applied to a 31-variable dataset of PDODD covariates (18 continuous, 13 binary) from the National Health and Nutrition Examination Survey and compared to a tabular variational autoencoder (TVAE). For nivolumab PK data (12,000 patients, 13 time points, 5 covariates), sequence-based diffusion model (SDM) and a time-aware diffusion model (TDM) with temporal self-attention were evaluated. The predictive performance of the TDM was evaluated by imputing masked time points. All models were trained and tested on 80%:20% partitions of the data using univariate, bivariate, and multivariate distributional similarity metrics. The diffusion model satisfactorily approximated the univariate distributions of continuous PDODD biomarkers (mean Kolmogorov-Smirnov D-statistic, KSD = 0.014), disease status frequencies (mean absolute error, MAE = 0.31%), and preserved bivariate correlations (MAE = 0.033). DDPM outperformed TVAE for categorical variables (0.31% vs. 1.07% MAE) and correlation (0.033 vs. 0.091 MAE). For nivolumab PK, SDM has KSD of 0.047 and a relative error of 1.36%. TDM accurately imputed missing PK timepoints (KSD = 0.014), reconstructing masked Day 1, Peak concentration (Cmax) Dose-9, and Terminal phase concentrations with MAE of 0.43%, 0.25%, and 0.76%, and correlations ≥ 0.999. Diffusion models demonstrated strong performance in generating cross-sectional PK covariate data and longitudinal PK profiles, capturing complex distributional and temporal dependencies. Diffusion-based approaches provide a flexible and robust framework for virtual simulations in pharmacometrics.