Scholarlink

<p>In this study, we developed a thermo-responsive nanocarrier by functionalizing carboxylated nanodiamonds with a copolymer of N-vinylcaprolactam and vinylacetic acid to deliver metformin for diabetes treatment. The composite was characterized using various analyses, such as X-ray diffraction, thermogravimetric analysis, Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, energy-dispersive X-ray, dynamic light scattering, and zeta potential. Using the central composite design of response surface methodology, we determined the optimal operational parameters, such as solution pH, contact time, and temperature, which yielded a maximum drug adsorption efficiency of 93% at a pH of 7, a contact time of 35&#xa0;min, and temperature of 30&#xa0;°C. The non-linear pseudo-second-order kinetic and Langmuir isotherm models provided the best fit for the experimental data. Drug release studies revealed that elevated temperatures at pH 7.4 enhanced metformin release (99.02%) compared to physiological conditions at 37&#xa0;°C (59.20%) over 6&#xa0;h. Additionally, near-infrared light irradiation triggered complete relative drug release within 20&#xa0;min, whereas the non-irradiated system exhibited only 28.18 ± 0.025% release, demonstrating rapid drug delivery. The Korsmeyer-Peppas model indicated a non-Fickian diffusion mechanism with an initial burst release at both temperatures, further confirming the potential of the system for on-demand therapeutic applications. According to cytotoxicity test, the nanocomposite exhibits significantly lower cytotoxicity compared to drug-loaded nanocomposite against HepG2 cancer cells, confirming improved biocompatibility.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Construction of a Nanocarrier Incorporating Carboxylated Nanodiamonds with a Thermo-Responsive Polymer with Sequential Free Radical Polymerization for the Treatment of Diabetic Diseases

  • 期刊论文

  • 发表日期：

    2026年6月17日

查看全文
  • Niloufar Kefayati,
  • Homayon Ahmad Panahi,
  • Mahboobeh Manoochehri,
  • Elham Moniri,
  • Fariba Tadayon

摘要

In this study, we developed a thermo-responsive nanocarrier by functionalizing carboxylated nanodiamonds with a copolymer of N-vinylcaprolactam and vinylacetic acid to deliver metformin for diabetes treatment. The composite was characterized using various analyses, such as X-ray diffraction, thermogravimetric analysis, Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, energy-dispersive X-ray, dynamic light scattering, and zeta potential. Using the central composite design of response surface methodology, we determined the optimal operational parameters, such as solution pH, contact time, and temperature, which yielded a maximum drug adsorption efficiency of 93% at a pH of 7, a contact time of 35 min, and temperature of 30 °C. The non-linear pseudo-second-order kinetic and Langmuir isotherm models provided the best fit for the experimental data. Drug release studies revealed that elevated temperatures at pH 7.4 enhanced metformin release (99.02%) compared to physiological conditions at 37 °C (59.20%) over 6 h. Additionally, near-infrared light irradiation triggered complete relative drug release within 20 min, whereas the non-irradiated system exhibited only 28.18 ± 0.025% release, demonstrating rapid drug delivery. The Korsmeyer-Peppas model indicated a non-Fickian diffusion mechanism with an initial burst release at both temperatures, further confirming the potential of the system for on-demand therapeutic applications. According to cytotoxicity test, the nanocomposite exhibits significantly lower cytotoxicity compared to drug-loaded nanocomposite against HepG2 cancer cells, confirming improved biocompatibility.