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<p>This study aimed to optimize a biocomposite formulation based on chitosan (CS) and periodate oxidized schizophyllan (POSPG), in order to develop a multifunctional platform suitable for biomedical applications, particularly wound-dressings. This research focuses on improving the key physicochemical and biological properties required for effective medical use. Schizophyllan (SPG) was produced by fermenting <i>Schizophyllum commune</i> and subsequently oxidized to yield aldehyde contents of 68%, 53%, and 32%. The CS/POSPG composites were prepared by varying aldehyde content and CS: POSPG volume mixing ratios (1, 2, 3). The mixing ratio strongly influenced tensile strength (TS) and swelling capacity, whereas aldehyde content primarily governed the barrier properties. The optimal formulation was evaluated using criteria that included TS, swelling behavior, water-vapor permeability (WVP), hydrophilicity, and cytocompatibility. The (CS/POSPG53)₃ composite—prepared with POSPG53 (aldehyde content of 53%) at a CS: POSPG ratio of 3—was identified as optimal, exhibiting TS of 63.49 ± 0.7&#xa0;MPa, swelling ratio of 4.43 ± 0.08, WVP of 0.58 ± 0.007&#xa0;mm·g/m²·h·kPa, contact angle of 78°, and cell viability of 83.4 ± 0.93%. Structural characterization of (CS/POSPG53)₃ by ¹H-NMR and FTIR confirmed Schiff-base formation, while XRD revealed its reduced crystallinity compared to CS film. TGA and DSC demonstrated enhanced thermal stability. This film showed antimicrobial activity, with inhibition rates of 52.8 ± 2.07% against <i>S. aureus</i>, 56.1 ± 1.65% against <i>E. coli</i>, 48 ± 1.95% against MRSA, 56.8 ± 3.06% against <i>P. aeruginosa</i>, and 44.2 ± 0.98% against <i>Candida</i>. Overall, these findings highlight (CS/POSPG53)₃ as a promising biomaterial that combines antimicrobial efficacy, cytocompatibility, and favorable physicochemical properties, underscoring its potential for wound management applications.</p>

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Design and Optimization of Bio-based Chitosan/oxidized Schizophyllan Hydrogel film: A Versatile Platform for Wound Dressing Applications

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Samaneh Ghorbanzadeh,
  • Sepideh Hamedi,
  • Seyed Abbas Shojaosadati

摘要

This study aimed to optimize a biocomposite formulation based on chitosan (CS) and periodate oxidized schizophyllan (POSPG), in order to develop a multifunctional platform suitable for biomedical applications, particularly wound-dressings. This research focuses on improving the key physicochemical and biological properties required for effective medical use. Schizophyllan (SPG) was produced by fermenting Schizophyllum commune and subsequently oxidized to yield aldehyde contents of 68%, 53%, and 32%. The CS/POSPG composites were prepared by varying aldehyde content and CS: POSPG volume mixing ratios (1, 2, 3). The mixing ratio strongly influenced tensile strength (TS) and swelling capacity, whereas aldehyde content primarily governed the barrier properties. The optimal formulation was evaluated using criteria that included TS, swelling behavior, water-vapor permeability (WVP), hydrophilicity, and cytocompatibility. The (CS/POSPG53)₃ composite—prepared with POSPG53 (aldehyde content of 53%) at a CS: POSPG ratio of 3—was identified as optimal, exhibiting TS of 63.49 ± 0.7 MPa, swelling ratio of 4.43 ± 0.08, WVP of 0.58 ± 0.007 mm·g/m²·h·kPa, contact angle of 78°, and cell viability of 83.4 ± 0.93%. Structural characterization of (CS/POSPG53)₃ by ¹H-NMR and FTIR confirmed Schiff-base formation, while XRD revealed its reduced crystallinity compared to CS film. TGA and DSC demonstrated enhanced thermal stability. This film showed antimicrobial activity, with inhibition rates of 52.8 ± 2.07% against S. aureus, 56.1 ± 1.65% against E. coli, 48 ± 1.95% against MRSA, 56.8 ± 3.06% against P. aeruginosa, and 44.2 ± 0.98% against Candida. Overall, these findings highlight (CS/POSPG53)₃ as a promising biomaterial that combines antimicrobial efficacy, cytocompatibility, and favorable physicochemical properties, underscoring its potential for wound management applications.